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Celebrities Are Biohacking Their Bodies Against Cellular Aging With This ‘Longevity Molecule’
What unites tech biohacker Bryan Johnson, model Hailey Bieber, and actress Jennifer Aniston?
By Liz N., Health Editor
Published August 14, 2025 6:15 a.m.
Aside from being ‘A-listers’ (in tech, wellness, and entertainment, respectively), they all plan on aging in reverse.
They’ve all been connected to NAD+, a molecule gaining buzz as a possible secret to cellular longevity.
— Dr. David Sinclair, Professor of Genetics, Harvard Medical School, as quoted in Boston Magazine (2019)
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This decline reduces mitochondrial function and DNA repair, increasing age-related issues like cognitive, heart, and metabolic problems.
Until recently, NAD+ wasn’t easy to supplement directly. It’s unstable and poorly absorbed. But scientific breakthroughs in the last decade have introduced precursors to NAD+ that can effectively replenish NAD+ levels.
By helping restore NAD+ levels, these precursors are thought to support healthy aging at the cellular level.
The most promising?
NR (Nicotinamide Riboside) has been shown in human studies to significantly increase NAD+ levels.
In a 2019 human study published in Cell Reports, older adults who supplemented with nicotinamide riboside (a precursor to NAD⁺) experienced increased NAD⁺ levels in blood and muscle tissue.
In animal research, scientists at Washington University School of Medicine and others have shown that boosting NAD⁺ levels in aged mice can improve vascular function, energy metabolism, and cognitive performance.
Supports energy production by facilitating the conversion of nutrients into usable cellular energy (ATP).
Enables DNA repair by acting as a substrate for enzymes like PARPs (poly ADP-ribose polymerases), which help fix damaged DNA.
Activates sirtuins, a family of enzymes linked to cellular stress resistance, metabolic regulation, and healthy aging.
Maintains mitochondrial function, which is vital for energy metabolism and overall cellular efficiency.
While celebrity endorsements have brought NAD+ and NR into the spotlight, it's the mounting scientific evidence that's capturing the attention of ‘biohackers’ everywhere. Though we still need more comprehensive human studies to fully understand long-term effects, early research suggests these compounds could revolutionize how we approach cellular aging
Time will tell. But its potential to extend healthspan and improve quality of life makes it one of the most compelling longevity supplements available today.
After analyzing dozens of products, looking at ingredient purity, absorption rates, and value for money, we found some great options.
*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
★★★★★
Based on 3739 Reviews of Primal Harvest
Supports healthy aging and cellular longevity
425 mg NR per serving (recommended dose)
425 mg Trans-Resveratrol
Top pick:
Tru Niagen
NAD+
by Life Extension
NiaCel 400
by Thorne
Nicotinamide Riboside
by Renue By Science
- 415 mg NR per serving
- 60-day returns policy
- High dose of NR per serving
- Non-GMO
- 300 mg NR per serving
- With small dose of Trans-Resveratrol
- 300 mg NR per serving
- 1-capsule serving size
Citations:
McReynolds, M. R., Chellappa, K., & Baur, J. A. (2020). Age-related NAD+ decline.
Experimental Gerontology, 134, 110888. https://doi.org/10.1016/j.exger.2020.110888