Common Perimenopause Symptoms

Every woman’s experience is unique, but many report:

Physical Changes

Pros

Cons

• Only available online
• Due to popularity, sometimes runs out of stock

Bottom Line

• Complete formula with 24 vitamins and minerals to support perimenopause transition*
• Includes GABA for mood and relaxation support*
• 2 easy-to-swallow capsules per day
• Third-party lab tested
• 90-day money-back guarantee

Based on 3739 Reviews of Primal Harvest

For many women, their late 30s and 40s come with changes they didn’t see coming.

Perimenopause is the transitional stage before periods stop completely. Hormones begin fluctuating, and that can affect how you feel physically, mentally, and emotionally.

• Complete formula with 24 vitamins and minerals to support perimenopause transition*
• Contains key nutrients for bone health including calcium, vitamin D3, and magnesium
• Includes GABA for mood and relaxation support*
• 90-day money-back guarantee
• Certified safety & purity testing

Primal Women+ by Primal Harvest features essential nutrients to support the body during perimenopause, including vitamins C, D3, E, A, and K, plus all 8 B-vitamins to support energy and mood. Key minerals like calcium, zinc, selenium, iodine, chromium, and magnesium provide added nutritional support during this stage. The formula also includes GABA to help support relaxation and sleep quality, along with a blend of Xanthogreen® lutein, astaxanthin from organic algae extract, and lycopene for antioxidant support.

The supplement comes in a convenient serving of just two capsules per day and is third-party lab tested and made in the USA. Primal Harvest’s ‘Subscribe & Save’ option will get you an extra 20% off plus free shipping, with additional discounts when purchasing multiple bottles.

Every order is backed by a 90-day money-back guarantee.

What Is Perimenopause?

Top Perimenopause Supplements 2026

TRY TO HAVE

GABA (for mood/relaxation support*)

Vitamin D3

Magnesium

Hormone-free formula

Women's Balance by Nutrafol

Estroven

Amberen

Hormone Harmony by Happy Mammoth

90-Day Money-Back Guarantee

Third Party Tested

Subscription Service

Note: We try to update product information as often as we can. Please visit product websites for more information.

Perimenopause is the phase leading up to menopause, when estrogen and progesterone levels begin to shift.

It can start as early as your mid-30s.

During perimenopause ovaries gradually produce less estrogen, causing hormonal fluctuations that can trigger various physical and emotional symptoms.

IMPORTANT CRITERIA

Top Pick

Hormonal shifts affect sleep, mood, temperature regulation, and energy.

While lifestyle habits matter (nutrition, movement, stress management), targeted supplements may help support your body during this transition.*

The key is choosing one formulated specifically for multi-symptom support - not just some generic women’s multivitamin.

How Long Does Perimenopause Last?

Perimenopause typically lasts 3 to 8 years before menopause, which is defined as going 12 months without a period.

Can Perimenopause Supplements Help?

★★★★★

*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 

Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Top5 Wellness has with our picks.

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What Makes a Good Perimenopause Supplement?

• GABA (Gamma-Aminobutyric Acid) 

A calming neurotransmitter that may help to quiet a “wired” mind and ease occasional feelings of stress and tension during menopause.*

• Magnesium

Thought to support restful sleep, calm nervous system function, and help balance mood, all key concerns as hormone levels fluctuate during perimenopause. It also works together  with vitamin D3 and calcium to support bone health.*

IMPRINT

• Only US brands reviewed

• Hormone-free options only

• Clinically studied ingredients prioritized

• Third-party tested brands only

Are You Experiencing Perimenopause Symptoms?

• Hot flashes*
• Night sweats*
• Sleep disruptions*

• Weight changes (especially midsection)*
• Low energy*
• Vaginal dryness*

Mental Changes

• Brain fog*
• Forgetfulness*
• Trouble focusing*

Emotional Changes

• Mood swings*
• Irritability*

• Feeling overwhelmed*
• Low motivation*

Note: If you're experiencing severe menopausal symptoms, please consult a healthcare professional. These statements are not intended to diagnose, treat, cure or prevent any disease. Always consult your personal physician for an accurate diagnosis and treatment plan.

Many women say it feels like they’ve lost control of their own body. Can you relate?

2. Women's Balance

Pros

Cons

• 4 capsules daily dosage may be high for some
• Contains fish (may not be suitable for some dietary preferences)

Bottom Line

• Features marine collagen and ashwagandha
• Includes antioxidants and vitamins
• Physician-formulated

Bonafide's Relizen is another strong contender. Like our top pick, it's safe, natural and hormone-free, making good use of premium botanicals to support your body during menopause.

Where Relizen may fall short (in some people's eyes) is the lack of one key ingredient: there's no Siberian rhubarb for clinically-proven perimenopause relief.

3. Estroven

Pros

Cons

• Limited mineral content
• No vitamins at all

Bottom Line

Estroven takes a plant-based approach to menopause relief with herbal ingredients like Rhapontic rhubarb and Ashwagandha. 

The formula is relatively minimalistic, lacking the vitamin and minerals found in higher-ranked options. This formula could be best suited for those seeking a simple, targeted herbal supplement rather than complete nutritional support during perimenopause.

• Contains Ashwagandha for stress management
• Soy-free, gluten-free, non-GMO

• Vitamin D3

Supports bone strength, muscle function, and immune health as estrogen naturally declines. It may also play a role in mood and overall vitality during and after menopause.*

4. Hormone Harmony

Pros

Cons

• 3-capsule daily dose may be inconvenient for some
• 24-day supply per bottle may cause frustration for some users

Bottom Line

• Natural, plant-based formula
• Free from artificial ingredients

Happy Mammoth's Hormone Harmony focuses on traditional botanicals and adaptogenic herbs, featuring supportive ingredients like Maca Root, Chaste Tree Berry, and Wild Yam.

The supplement requires a 3-capsule daily dose and provides only a 24-day supply per bottle. While the herbal blend is diverse, the higher capsule count may be off-putting for some. Additionally, the shorter supply cycle means more frequent reordering, which might be inconvenient for users trying to stay consistent with their routine. 

5. Amberen

Pros

Cons

• Proprietary blend - may raise dosage concerns
• Limited vitamin content (only Vitamin E)

Bottom Line

• Hormone-free, soy-free formula
• 2-capsule daily dosage

Amberen takes a unique mineral-based approach to perimenopause relief, backed by clinical trials and a hormone-free formula. 

However, its proprietary blend masks the exact amounts of key minerals like calcium, magnesium, and zinc - a stark contrast to higher-ranked options that clearly disclose all ingredient dosages. 

While the two-capsule serving is convenient, the limited transparency and vitamin content may make it a less attractive option for those seeking clear visibility into their supplement ingredients.

• Hormone-Free Design

Many women prefer non‑hormonal support that works with the body’s natural processes. Well‑designed formulas often focus on targeted nutrients for bones, mood, sleep, and daily wellbeing during perimenopause.*

• Third-Party Testing & Strong Guarantee

You want guaranteed purity and potency, plus enough time to decide if the product is right for you.