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HOW WE RANK

LATEST UPDATE:

Common Perimenopause Symptoms

Every woman’s experience is unique, but many report:

Physical Changes

1. Primal Meno+

by Primal Harvest[1]

Pros

Cons

Only available online
Due to popularity, sometimes runs out of stock

Bottom Line

Complete formula with 24 vitamins and minerals to support perimenopause transition*
Includes GABA for mood and relaxation support*
2 easy-to-swallow capsules per day
Third-party lab tested
90-day money-back guarantee

LEARN MORE

Based on 3739 Reviews of Primal Harvest

For many women, their late 30s and 40s come with changes they didn’t see coming.

Perimenopause is the transitional stage before periods stop completely. Hormones begin fluctuating, and that can affect how you feel physically, mentally, and emotionally.

Designed to relieve major perimenopause symptoms*
Safe, hormone-free, plant-based formula
With Siberian rhubarb at a clinically-effective dose (4 mg)
Features unique Chinese Harmony & Balance Blend
Easy-to-swallow, once-daily capsules
90-day money-back guarantee
Certified safety & purity testing

Primal Meno+ by Primal Harvest is an exciting new supplement specifically designed to support women during perimenopause and beyond. The formula features clinically-studied ingredients such as Siberian Rhubarb and Saffron Flower Extract, alongside a supportive Chinese Harmony & Balance Blend, carefully crafted with 9 herbs traditionally associated with promoting hormonal balance, emotional well-being, and overall vitality during perimenopause.*

This premium formula is super convenient, taken once-daily. The plant-based capsules are easy-to-swallow and designed for delayed release, helping protect sensitive ingredients from stomach acid and deliver consistent support for women seeking menopausal comfort.

Meno+ is third-party lab tested and made in the USA. The brand also offers an optional Subscribe & Save program which gives you 20% off all products plus free shipping.

To top it off, Primal Harvest offers a 90-day money-back guarantee on all of their products, giving you plenty of time to try Primal Meno+ completely risk-free. If you don't like it, you can just send it back, no questions asked!

The Best Perimenopause Supplements in 2026

What Is Perimenopause?

Perimenopause Supplements: What Actually Works?

Perimenopause is the phase leading up to menopause, when estrogen and progesterone levels begin to shift.

It can start as early as your mid-30s.

During perimenopause ovaries gradually produce less estrogen, causing hormonal fluctuations that can trigger various physical and emotional symptoms.

Top Pick

1. Primal Meno+

by Primal Harvest[1]

Hormonal shifts affect sleep, mood, temperature regulation, and energy.

While lifestyle habits matter (nutrition, movement, stress management), targeted supplements may help support your body during this transition.*

The key is choosing one formulated specifically for multi-symptom support - not just some generic women’s multivitamin.

How Long Does Perimenopause Last?

Perimenopause typically lasts 3 to 8 years before menopause, which is defined as going 12 months without a period.

Can Perimenopause Supplements Help?

★★★★★

What Makes a Good Perimenopause Supplement?

Siberian Rhubarb

A clinically studied botanical that may help to support hormonal balance and relief from common perimenopausal symptoms like hot flashes, irritability, and mood changes.*

Plant-based capsules

Can be formulated for delayed release, which may help to protect sensitive ingredients from stomach acid and support absorption in the intestines.*

IMPRINT

If your cycle feels unpredictable, your mood shifts out of nowhere, and sleep just isn’t what it used to be… you’re not imagining it.

You might be entering perimenopause. We break down exactly what’s happening (and compare the top supplements designed to support you through it).

Only US brands reviewed

Hormone-free options only

Clinically studied ingredients prioritized

Third-party tested brands only

Are You Experiencing Perimenopause Symptoms?

Hot flashes*
Night sweats*
Sleep disruptions*

Weight changes (especially midsection)*
Low energy*
Vaginal dryness*

Mental Changes

Brain fog*
Forgetfulness*
Trouble focusing*

Emotional Changes

Mood swings*
Irritability*

Feeling overwhelmed*
Low motivation*

Note: If you're experiencing severe menopausal symptoms, please consult a healthcare professional. These statements are not intended to diagnose, treat, cure or prevent any disease. Always consult your personal physician for an accurate diagnosis and treatment plan.

Many women say it feels like they’ve lost control of their own body. Can you relate?

2. Relizen

by Bonafide

Pros

Cons

No Siberian rhubarb
30-day returns policy

Bottom Line

2-capsule serving size
Hormone-free formula
Good range of soothing botanicals

Bonafide's Relizen is another strong contender. Like our top pick, it's safe, natural and hormone-free, making good use of premium botanicals to support your body during menopause.

Where Relizen may fall short (in some people's eyes) is the lack of one key ingredient: there's no Siberian rhubarb for clinically-proven perimenopause relief.

3. Amberen

Pros

Cons

No traditional herbal extracts or botanicals
Not vegan (contains gelatin)

Bottom Line

Amberen takes a different approach to perimenopause relief with its fun gummy format and hormone-free formula. While the gummies are sugar-free and hormone-free, they do contain gelatin, which could make them unsuitable for those following a plant-based or vegetarian diet.

The formula leans heavily on minerals, antioxidants and amino acids but lacks any of the recommended herbal extracts or botanicals featured in this guide, which those seeking more comprehensive, plant-based support may consider a drawback.

Sugar-free gummies
Hormone-free

Saffron

Known as the 'sunshine spice' due to its potential positive effects on mood, emotional balance, and overall well-being.*

4. Hormone Harmony

by Happy Mammoth

Pros

Cons

3-capsule daily dose may be inconvenient for some
24-day supply per bottle may cause frustration for some users

Bottom Line

Natural, plant-based formula
Free from artificial ingredients

Happy Mammoth's Hormone Harmony focuses on traditional botanicals and adaptogenic herbs. The formula features supportive ingredients like Maca Root, Chaste Tree Berry, and Wild Yam, but noticeably lacks some of the popular ingredients for perimenopause support, with Siberian Rhubarb being a notable omission.

The supplement requires a 3-capsule daily dose and provides only a 24-day supply per bottle. While the herbal blend is diverse, the higher capsule count may be off-putting for some. Additionally, the shorter supply cycle means more frequent reordering, which might be inconvenient for users trying to stay consistent with their routine.

5. Estroven

Pros

Cons

30-day money-back guarantee
Lacks comprehensive ingredient profile of top competitors

Bottom Line

Plant-based caplets
Soy-free, gluten-free, non-GMO

Estroven is the second product on this list to feature clinically studied Siberian Rhubarb, taking an effective yet minimalistic approach to perimenopause support.

While the formula is a solid starting point, it may benefit from a more comprehensive blend, including additional clinically-backed herbs or botanicals to offer broader potential support during the menopausal transition.

Unlike some higher-ranked options with more generous return policies, Estroven’s 30-day window may not offer enough time for users to fully assess its effectiveness.

Hormone-Free Design

Many women prefer non‑hormonal support that works with the body’s natural processes. Well‑designed formulas often focus on targeted nutrients for bones, mood, sleep, and daily wellbeing during perimenopause.*