Primal NAD+ stands out for its research-backed doses of Nicotinamide Riboside and Trans-Resveratrol - two of the most effective and well-studied ingredients for supporting NAD+ levels, cellular energy, and healthy aging.

We especially liked the addition of two unique cellular nutrients: Betaine, which supports metabolism and DNA repair, and CoQ10, which enhances mitochondrial energy and helps combat oxidative stress.

Of all the products we reviewed, none offered such a well-rounded combination at such effective doses. The simple 2-capsule serving makes it easy to stay consistent, and it’s backed by a 90-day money-back guarantee, an industry gold standard. While it may not be widely available in stores, Primal NAD+ is our top pick for the best NAD+ supplement of 2025.

What to Look For (and What to Avoid) in NAD+ Supplements

Choosing the right NAD+ supplement doesn’t have to be complicated. Here’s what you should prioritize:

Try To Look For

Try To Avoid

What To Look For:

Important Criteria

NAD+ by Life Extension

NiaCel 400

by Thorne

90-Day Money-Back Guarantee

Third Party Tested

Subscription Service

*Based on the individual experience of the Smarter Choices team and on a number of user reviews of the product. 

Note: We try to update product information as often as we can. Please visit product websites for more information. 

PROS

• 300 mg NR per serving
• With Trans-Resveratrol
• Competitive returns policy

CONS

• Features proprietary blends
• Trans-Resveratrol dose (10 mg) falls well under recommendations

BOTTOM LINE

NAD+ by Life Extension provides 300 mg NR per serving and includes Trans-Resveratrol, but the 10 mg dose is well below the recommended 250 mg minimum. Its proprietary blends add unneeded complexity to the formula, which may not appeal to those seeking transparency. It offers a one-year return policy, but opened products might not be eligible - unlike our top pick, which accepts returns hassle-free.

C+

GRADE

PROS

• 300 mg NR per serving
• 1-capsule serving size
• No artificial colors

CONS

• 30-day returns window
• Lacks additional support for healthy aging

BOTTOM LINE

Tru Niagen delivers a convenient 1-capsule serving with 300 mg of NR and, like all products on this list, contains no artificial colors or flavors. Unfortunately, its 30-day return window is the shortest here, and it lacks additional key ingredients for further support. For those wanting straightforward NAD+ support, it’s a viable choice. However, other options on this list offer higher NR doses and more comprehensive formulas that some may find better value.

B

GRADE

by Renue By Science

PROS

• High dose of NR per serving 
• Non-GMO
• Made in a GMP compliant facility

CONS

• No Trans-Resveratrol 
• Lacks other key supporting ingredients 

BOTTOM LINE

Nicotinamide Riboside by Renue By Science is a good option for those who want a high dose of NR and no additional support for healthy aging and cellular longevity. Those seeking more comprehensive formulas may prefer other options on this list.

B+

GRADE

PROS

• 415 mg NR per serving
• With Betaine
• 60-day returns policy

CONS

• Trans-Resveratrol
• Betaine dose inferior to top pick

BOTTOM LINE

NiaCel 400 by Thorne is a solid choice from a trusted brand, with a 60-day return policy. It provides a good dose of NR and includes 85 mg of betaine to support DNA repair - though this amount is much lower than our top pick (which offer over five times more). While those seeking more competitive doses may want to look elsewhere, NiaCel 400 remains a reliable option for NAD+ support.

C

GRADE

PROS

CONS

• May not be as widely available in retail stores as larger brands

BOTTOM LINE

A+

GRADE

• Supports healthy aging and cellular longevity
• 425 mg Nicotinamide Riboside Chloride (NR) per serving (recommended dose)
• 425 mg Trans-Resveratrol 
• With 300 mg Betaine (Trimethylglycine) and 100 mg Coenzyme Q10 (Ubiquinone)
• Convenient 2-capsule serving size
• Made in a GMP compliant facility
• 90-day money-back guarantee

DISCLAIMER: This scientific research is for informational purposes only. The results reported may not necessarily occur in all individuals. Primal Harvest provides this information as a service but does not endorse it. This information should not be read to recommend or endorse any specific products.

Trammell, S. a. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 7(1). https://doi.org/10.1038/ncomms12948

Damgaard, M. V., & Treebak, J. T. (2023). What is really known about the effects of nicotinamide riboside supplementation in humans. Science Advances, 9(29). https://doi.org/10.1126/sciadv.adi4862

Yang, X., Lu, A., Guan, X., Ying, T., Pan, J., Tan, M., & Lu, J. (2024). An updated review on the mechanisms, Pre‐Clinical and clinical comparisons of nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). Food Frontiers. https://doi.org/10.1002/fft2.511

Dellinger, R. W., Santos, S. R., Morris, M., Evans, M., Alminana, D., Guarente, L., &

Marcotulli, E. (2017). Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. Npj Aging and Mechanisms of Disease, 3(1). https://doi.org/10.1038/s41514-017-0016-9

CITATIONS

Our 2025 Recommendation

Nicotinamide Riboside Chloride (NR)

Trans-Resveratrol

HPMC Capsules: 

2. Nicotinamide Riboside

5. Tru Niagen

4. NAD+

by Life Extension

3. NiaCel 400

Based on 3739 Reviews of Primal Harvest

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a vital molecule found in every cell of your body. Your cells need NAD+ to produce energy, repair themselves, and even function properly.

When NAD+ declines, your body’s ability to create energy and repair itself starts breaking down and the aging process accelerates.

Nicotinamide Riboside by Renue By Science

​

Tru Niagen

• US-Made with Globally Sourced Ingredients
• Supports healthy aging and cellular longevity
• Made in GMP facility and Third-Party Tested
• 90-Day Money-Back Guarantee

Top NAD+ Supplements in 2025

Your NAD+ levels may already be crashing. Here’s what that could mean for you:

A drained, sluggish feeling halfway through the day

If you’re past the age of 30, your body’s natural NAD+ levels may have already started to plummet, and the decline may accelerate as you age.

The problem? Most people don’t realize plummeting NAD+ levels could be causing:

Slower recovery after workouts or sports

What are the benefits of NAD+ supplements?

Physical & Cellular Benefits

• Supporting healthy aging and maintaining cellular function.*
• Promoting DNA repair and cellular regeneration.*

Note: Benefits are based on personal experiences and feedback. Individual results may vary.

While everyone’s experience is different, NAD+ supplements have gained massive amounts of hype, helping people feel like they’re turning back the clock with a wide range of benefits:

Energy & Vitality

• Helping preserve physical performance and independence as you age.*

• Boosting cellular energy production for daily activities.*
• Reducing feelings of fatigue and sluggishness.*

• Supporting recovery from physical and mental exertion.*

by Thorne

What To Avoid

No Artificial Sweeteners

That’s why many people are now turning to supplements to restore NAD+ and stay energized from the inside out.

• Unproven Precursors: Unknown or new precursors may be a waste of money at best, or even cause serious harm. Stick to Nicotinamide Riboside (NR) for a precursor that’s been proven to boost NAD+ levels in clinical studies.
• Too Many Ingredients: Supplements with long ingredient lists often include unnecessary fillers. Aim for supplements with no more than 5 key ingredients. 
• Wrong Dosage: Taking too little won’t give you benefits; taking too much might cause side effects like stomach upset or flushing. Stick to research-backed doses, which can be found in the supplements we recommend below.

• Nicotinamide Riboside (NR): Turns into NAD+ inside your cells, helping them make energy and repair themselves. Aim for about 250-500 mg a day to support steady energy and cell health.
• Trans-Resveratrol: An antioxidant that protects your cells and helps NAD+ work better. Taking 250-500 mg daily can boost your cell’s health and defense against damage.
• Betaine (Trimethylglycine): Helps turn NR into usable NAD+ and supports your body’s natural DNA repair processes. Around 250 mg daily helps maintain healthy cell functions.
• Plant-Based (Hypromellose) Capsules: These protect the ingredients in the supplement and help your body absorb them faster.
• Third-Party Testing: Check for labs that verify the supplement is pure and contains exactly what’s on the label.

NAD+ supplements: How they can help

Steady, noticeable energy throughout the day

Taking NAD+ supplements may help your body feel younger and work better. People often notice:

Faster recovery after exercise or physical activity

NAD+ vs NR: What’s the difference?

Taking NAD+ directly as a supplement might not work well because your body can have trouble absorbing it properly.

That’s why NAD+ supplements contain NR instead. When you take NR, your body turns it into NAD+. Studies show that taking NR supplements can reliably increase the amount of NAD+ in your body, helping your cells get more energy and repair better.

NR (nicotinamide riboside) is a type of vitamin B3 that your body can change into NAD+.

NAD+ is a molecule inside your cells that helps them make energy and stay healthy.

Struggle with retaining information or focusing on tasks

Your body to feel older than it should

Better focus and clearer thinking

Stronger, healthier cells and support for repairing DNA

Overall support for healthy aging from the inside out

Note: Benefits are based on personal experiences and feedback. Individual results may vary.