Common perimenopause and menopausal symptoms:

During menopause, estrogen levels naturally decline, leading to a variety of changes in the body. Targeted supplemental support may help ease this transition, but it’s important to know how to choose the right supplement for your needs.

Understanding supplements during menopause

Hormonal Imbalance*

Mood fluctuations*

Sleep disruptions*

Memory and focus challenges*

Vaginal dryness*

Energy level fluctuations*

Note: If you're experiencing severe menopausal signs, please consult a healthcare professional. These statements are not intended to diagnose, treat, cure or prevent any disease. Always consult your personal physician for an accurate diagnosis and treatment plan.

Smart supplementation may help to provide relief during all stages of menopause. Here's how to find the right fit for your needs...

During perimenopause, menopause and postmenopause, many women explore natural options to support their changing bodies. While everyone's experience is unique, maintaining proper nutrition becomes especially important during this transition. Let's explore how different nutrients may help support your wellness journey.*

All menopause supplements are NOT created equal

Before rushing to purchase the first menopause supplement you see, there are important factors to consider to ensure you're getting a quality product that meets your specific needs.

*Note: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Ultimate Menopause Supplement Checklist:

Key Ingredients To Look For In Your Menopause Supplement*

What To Look For:

Important Criteria

Hormone Harmony by Happy Mammoth

Amberen

90-Day Money-Back Guarantee

Third Party Tested

Subscription Service

Note: We try to update product information as often as we can. Please visit product websites for more information.

PROS

• Natural, plant-based formula
• Free from artificial ingredients

CONS

• 3-capsule daily dose may be inconvenient for some
• 24-day supply per bottle may cause frustration for some users

BOTTOM LINE

Happy Mammoth's Hormone Harmony focuses on traditional botanicals and adaptogenic herbs. The formula features supportive ingredients like Maca Root, Chaste Tree Berry, and Wild Yam, but noticeably lacks some of the popular ingredients for menopause support, with Siberian Rhubarb being a notable omission.

The supplement requires a 3-capsule daily dose and provides only a 24-day supply per bottle. While the herbal blend is diverse, the higher capsule count may be off-putting for some. Additionally, the shorter supply cycle means more frequent reordering, which might be inconvenient for users trying to stay consistent with their routine. 

C+

GRADE

PROS

• Plant-based caplets
• Soy-free, gluten-free, non-GMO

CONS

• 30-day money-back guarantee
• Lacks comprehensive ingredient profile of top competitors

BOTTOM LINE

Estroven is the second product on this list to feature clinically studied Siberian Rhubarb, taking an effective yet minimalistic approach to menopause support.

While the formula is a solid starting point, it may benefit from a more comprehensive blend, including additional clinically-backed herbs or botanicals to offer broader potential support during the menopausal transition.

Unlike some higher-ranked options with more generous return policies, Estroven’s 30-day window may not offer enough time for users to fully assess its effectiveness.

​

C

GRADE

by Bonafide

PROS

• 2-capsule serving size
• Hormone-free formula
• Good range of soothing botanicals 

CONS

• No Siberian rhubarb
• 30-day returns policy

BOTTOM LINE

Bonafide's Relizen is another strong contender. Like our top pick, it's safe, natural and hormone-free, making good use of premium botanicals to support your body during menopause.

Where Relizen may fall short (in some people's eyes) is the lack of one key ingredient: there's no Siberian rhubarb for clinically-proven menopause relief.

The 2-capsule serving size might be inconvenient for some.

Unfortunately, the 30-day returns window may not be enough time for some users to see if this product is right for their needs.

B+

GRADE

PROS

• Sugar-free gummies
• Hormone-free

CONS

• No traditional herbal extracts or botanicals
• Not vegan (contains gelatin)

BOTTOM LINE

Amberen takes a different approach to menopause relief with its fun gummy format and hormone-free formula. While the gummies are sugar-free and hormone-free, they do contain gelatin, which could make them unsuitable for those following a plant-based or vegetarian diet.

The formula leans heavily on minerals, antioxidants and amino acids but lacks any of the recommended herbal extracts or botanicals featured in this guide, which those seeking more comprehensive, plant-based support may consider a drawback.

B

GRADE

PROS

CONS

• Only available online
• Due to popularity, sometimes runs out of stock

BOTTOM LINE

A+

GRADE

• Designed to support major menopausal symptoms*
• Safe, hormone-free, plant-based formula
• With Siberian rhubarb at a clinically-effective dose (4 mg) 
• Features unique Chinese Harmony & Balance Blend
• Easy-to-swallow, once-daily capsules
• 90-day money-back guarantee
• Certified safety & purity testing

[1] “Office of Dietary Supplements - Multivitamin/Mineral Supplements.” NIH Office of Dietary Supplements, U.S. Department of Health and Human Services, https://ods.od.nih.gov/factsheets/MVMS-HealthProfessional/. 

[2] “Vitamins and Minerals.” National Center for Complementary and Integrative Health, U.S. Department of Health and Human Services, https://www.nccih.nih.gov/health/vitamins-and-minerals. 

[3] “Office of Dietary Supplements - Calcium.” NIH Office of Dietary Supplements, U.S. Department of Health and Human Services, https://ods.od.nih.gov/factsheets/Calcium-HealthProfessional/. 

To see a list of our other references, please click here. 

CITATIONS

Our Choice

Multi-symptom support

Plant-based capsules

Hormone-free formula

Siberian rhubarb

2. Relizen

5. Estroven

4. Hormone Harmony

by Happy Mammoth

3. Amberen

Based on 3739 Reviews of Primal Harvest

The 3 Stages Of Menopause

Perimenopause

• Periods become unpredictable*
• Changes in mood and sleep start*

Note: Benefits are based on personal experiences and feedback. Individual results may vary.

Menopause includes three distinct stages that many women go through:

Menopause

• Lasts 3-7 years for most women*

• Periods have stopped for a full year*
• Peak of hot flashes, night sweats and other signs*

• Can happen naturally or with surgery*

Postmenopause

• Menopause signs less frequent*
• Many report feeling more 'free' during this stage*

• Extra nutrients become crucial*

Weight changes, hot flashes, night sweats and other common menopausal symptoms

Weight changes, especially around the midsection, are seen by many as a normal part of menopause. Changing estrogen levels may affect:

• How fat is stored
• Muscle mass 
• Metabolism 

The good news? Many women find this is a great time to focus on their health. Maintaining a healthy weight during menopause may be easier when you focus on proper nutrition and regular exercise.

Estrogen decline may cause multiple issues for women:

Physical changes commonly include hot flashes and night sweats, which may lead to poor sleep quality and low energy levels.

Mental changes may include 'brain fog', irritability and lack of control over mood, which might make it difficult to self-regulate.

Remember: Every woman's experience is unique - here are some more common symptoms to look out for:

Hot flashes*

Weight changes*

Relizen by Bonafide

Estroven

Many menopause symptoms are linked to shifts in hormone levels—especially the natural decline and fluctuation of estrogen. A diet rich in nutrients such as calcium, vitamin D, B vitamins, magnesium and protein may help to alleviate menopausal symptoms. Many ancient herbs and botanicals are also being studied for their potential ability to help the body during this time, such as saffron, chinese foxglove and white peony.*

• Siberian Rhubarb (Rheum rhaponticum L.): A clinically studied botanical that may help to support hormonal balance and relief from common menopausal symptoms like hot flashes, irritability, and mood changes. It has been used to support menopausal symptoms since 1993.*
• Chinese Foxglove (Rehmannia glutinosa): A traditional herb thought to support adrenal health and hormonal regulation, plus energy, resilience, and overall vitality during menopause.*
• White Peony (Paeonia lactiflora): Traditionally thoughtto support emotional balance and hormone harmony, this botanical may help ease mood swings and promote a sense of calm during the menopausal transition.*
• Dodder Seed (Cuscuta chinensis): An adaptogenic herb traditionally used in Chinese medicine, thought to support reproductive and kidney health, which may also promote energy and overall wellness.*
• Saffron (Crocus sativus): Known as the 'sunshine spice' due to its potential positive effects on mood, emotional balance, and overall well-being. Emerging clinical research suggests that saffron may help promote a positive outlook, support healthy stress response, and contribute to comfort during the menopausal transition.*

• Quality of Ingredients: Consider supplements made with clinically studied ingredients. The most reliable menopause supplements often include well-researched compounds supported by science.
• Plant-based capsules:  Can be formulated for delayed release, which may help to protect sensitive ingredients from stomach acid and support absorption in the intestines.
• Hormone-Free: Many women prefer a natural, non-hormonal approach to menopause support. Consider supplements that are hormone-free and shown to be safe in clinical or traditional use.
• Third-Party Testing:  Supplements that have been independently tested for purity and potency. This ensures you're getting what's on the label without unwanted contaminants.

KEY FEATURES:

• Made to support relief from major menopausal symptoms*
• With Siberian rhubarb at a clinically-effective dose (4 mg) 
• Easy-to-swallow, once-daily capsules 
• Third-party lab tested
• 90-day money-back guarantee

TOP MENOPAUSE SUPPLEMENTS 2025

Primal Meno+ by Primal Harvest is an exciting new supplement specifically designed to support women during every stage of menopause. The formula features clinically-studied ingredients such as Siberian Rhubarb and Saffron Flower Extract, alongside a supportive Chinese Harmony & Balance Blend, carefully crafted with 9 herbs traditionally assosciated with promoting hormonal balance, emotional well-being, and overall vitality throughout the menopausal transition.*

This menopause support formula is super convenient, taken once-daily. The plant-based capsules are easy-to-swallow and designed for delayed release, helping protect sensitive ingredients from stomach acid and deliver consistent support for women seeking menopausal comfort.

Meno+ is third-party lab tested and made in the USA. The brand also offers an optional Subscribe & Save program which gives you 20% off all products plus free shipping. 

To top it off, Primal Harvest offers a 90-day money-back guarantee on all of their products, giving you plenty of time to try Primal Meno+ completely risk-free. If you don't like it, you can just send it back, no questions asked!