We’ve already covered the key nutrients to be on the lookout for when shopping for supplements for liver health. Here we’ve condensed some of the factors you might want to pay attention to when choosing a liver support supplement. 

What To Try To Avoid In A Liver Supplement*:

Although our liver is one of the most active organs, we can sometimes take it for granted. A variety of lifestyle choices such as excess alcohol, lack of exercise, or poor diet may impact the liver’s ability to function optimally. 

This is why some people may turn to practices, foods, and nutrients they believe could help such as a so-called “liver flush” with foods thought to “cleanse” the liver, liver detox tea, or vitamins for liver detoxification.

In this article, we will go through the basics of how the liver works, why it’s important to support your liver health, and learn more about the ingredients often found in liver support supplements. 

TOP LIVER SUPPLEMENTS IN 2025

What To Look For

Things To Look Out For 

Other Criteria

90-Day Money-Back Guarantee

Third Party Tested

Subscription Service

Liver Cleanse by Thorne

Liverwell by Live Conscious 

Liver Health Formula by Pure Health

LiverMD by 1MD Nutrition

What are liver support supplements?

• Support detoxification*
• Support overall liver health*
• Support liver function*

Liver supplements are intended to support the basic functions of your liver. They typically contain nutrients such as vitamins, minerals, and plant or herbal extracts that are thought to nourish and support the liver.

They may also:

• Noticing smooth digestion*
• Feeling generally energized*

​

• Not noticing issues with the liver*

​

• Noticing energy*
• Feeling a sense of regularity*
• Feeling like they have more metabolism support*

How might you benefit from a liver supplement?*

 Everyone has individual needs and the experience of making changes in your wellness routine will vary from person to person. Here are some examples of how including more daily liver supplement support may look for different people*:

6 + Months

3 – 6 Months

1 – 2 Months

Note: Individual results may vary. The benefits stated are based on personal experiences and subjective feedback and may vary from person to person.

• Support the production of bile*
• Support metabolism and weight maintenance*

Nutrients to look for in a liver supplement*:

• Holistic formula 
• Formulated with milk thistle, alpha lipoic acid, and selenium
• Contains antioxidants and amino acids
• Features premium Metabolyte™
• With brown algae and spirulina
• Price
• Third-party lab tested 

PROS

CONS

• Only available online
• Due to popularity, sometimes runs out of stock

Primal Liver by Primal Harvest is an all-in-one liver support supplement that features ingredients such as milk thistle (silymarin), alpha lipoic acid, selenium, zinc, vitamin E, berberine, amino acids like l-cysteine and l-glutathione, Curcumin C3 Complex®, uva ursi, brown seaweed, and spirulina. Also, a highlight of this formula is the addition of Metabolyte™ which is the world’s first research-backed branded phaseolusate for metabolism support.* 

More than just a milk thistle supplement, this premium formula is delivered in capsules, which our team felt were easy to take. We appreciated that the product is available for a fair price, and liked that it has such a wide range of ingredients. Primal Liver is a third-party lab tested and made in the USA with globally sourced ingredients. The brand also offers a convenient Subscribe & Save program which means you can order Primal Liver through their convenient and hassle-free subscription service. By signing up for a subscription you get 20% off all products plus free shipping. The brand’s excellent customer service scores and 90-day money-back guarantee. 

BOTTOM LINE

GRADE

*Price per day based on a one-time-purchase 30-day supply.

Note: We try to update product information as often as we can. Please visit product websites for more information. 

• Contains 125 mg milk thistle (silymarin) 
• Third-party tested

2. Liver Cleanse

by Thorne

PROS

CONS

• No vitamin E, zinc, or amino acids
• 60-day money back guarantee

Liver Cleanse by Thorne features 125 mg of milk thistle with the active ingredient silymarin as well as 125 mg of berberine. Liver Cleanse by Thorne is also dairy-free and soy-free making it suitable for various diets. However, it doesn't contain other ingredients such as vitamin E, zinc, and amino acids.

BOTTOM LINE

B+

GRADE

• Contains NAC (N-Acetyl Cysteine, a form of L-cysteine), ALA, and milk thistle 
• With zinc and selenium

3. Liverwell

Liverwell by Live Conscious

PROS

CONS

• No algae extract or curcumin
• No vitamin E

Liverwell by Live Conscious is a 2 capsule daily liver supplement that features many of the ingredients to look for such as zinc, selenium, NAC, and ALA. It also features a branded milk thistle extract called Siliphos®. However, it did not contain algae extract, curcumin, or vitamin E.

BOTTOM LINE

B

GRADE

• 500 mg of L-cysteine 
• With turmeric, beetroot, and milk thistle
• 365-day money-back guarantee

4. Liver Health Formula

by Pure Health

PROS

CONS

• Only 50 mg of milk thistle (silymarin) 
• Contains vitamin D but not vitamin E

Liver Health Formula by Pure Health is a liver health supplement that features turmeric (curcumin), beetroot, L-cysteine, and milk thistle, amongst other ingredients. We liked that the product contains a variety of ingredients and comes with a 365-day money-back guarantee. That gives you a year to try the product and see if it works for you. However, the product only contains 50 mg of milk thistle which is less than some of the other products on this list.

BOTTOM LINE

C+

GRADE

• Features 500 mg NAC (L-cysteine)
• With ALA, vitamin E, zinc, and Siliphos®
• 90-day money-back guarantee 

5. LiverMD

LiverMD by 1MD Nutrition

PROS

CONS

• No algae extract 
• No curcumin

LiverMD by 1MD Nutrition is a doctor-formulated liver support supplement made in the USA with patented ingredients such as TocoGaia™(vitamin E) and Siliphos® (milk thistle). The best part of this product is that it contains 500 mg of N-Acetyl Cysteine and also that it features similar ingredients to those found in our number one choice. However, it was lacking a few ingredients such as algae and curcumin. 

BOTTOM LINE

C

GRADE

Our Choice

• With lutein, zeaxanthin, and vitamin E
• Easy-to-swallow, 2-capsule serving
• Certified safety & purity testing
• 90-day money-back guarantee
• Made in the USA with globally sourced ingredients

CITATIONS

Based on 3732 Reviews of Primal Harvest 

What does the liver do? 

The liver has vital functions for our body such as converting nutrients into energy, eliminating toxins from our body, and maintaining stable blood sugar levels. 

In other words, our livers are there to support metabolism, immune health, digestion, detoxification, vitamin storage, and other essential bodily functions.[1,2] 

One of the main functions of the liver is to produce a substance called bile which helps to carry away waste and break down fats during digestion. After your stomach and intestines initially break down nutrients, the liver gets to work further breaking down substances that may be harmful and helping to filter them out of the body with help from your kidneys.[3] 

Why is it important to take care of your liver? 

Because your liver is responsible for further metabolic function and ridding your body of toxins, it’s a pretty important organ to take care of.[1,2,3,4] 

By providing your body with the proper nutrients, physical activity, and hydration, you can help your liver do the job it’s meant to do. When we lack certain nutrients or live a more sedentary lifestyle, we could be influencing our liver in a negative way.[4] 

Think of your body as you think of your house. You want to keep it clean and functional, right? In order to do so, you need the right tools (or organs) to help you keep up with daily maintenance. 

Liver and Metabolism: How Does Your Weight Affect Liver Health?

Taking care of your overall health through nutrition and exercise generally reduces the risk of becoming overweight. This is especially important when it comes to the function of your liver.

Studies suggest that body weight gain in adulthood may negatively impact your liver’s ability to metabolize food.[5] Furthermore, if your liver is slow to metabolize, it may be a cause for weight gain. Essentially, your liver plays a role in maintaining your body weight and your weight contributes to the overall health of your liver. 

Who might potentially benefit from taking liver supplements?* 

• Feels they need additional digestive support* 
• Wants to support detoxification* 
• Follows a diet high in processed foods, saturated fats, sugar, salt, and alcohol*

Everyone’s needs are different, but some people who may benefit from taking liver supplements include anyone who:

• Experiences brain fog*
• Struggles to eat enough well-balanced meals due to their lifestyle or schedule*
• Wants overall liver health support*

Note: These statements are not intended to diagnose, treat, cure, or prevent any disease, nor are they intended to be substitutes for professional medical health advice. Always consult your physician or other qualified healthcare provider for accurate advice, diagnosis, and treatment plan.

Milk Thistle (Silymarin)

Alpha Lipoic Acid

Vitamin E

Algae

Amino Acids

Turmeric Curcumin

Zinc

Selenium

No Less Than 100 mg of Milk Thistle (Silymarin)

Price Per Day (Less Than $1)*

DISCLAIMER: This scientific research is for informational purposes only. The results reported may not necessarily occur in all individuals. Primal Harvest provides this information as a service but does not endorse it. This information should not be read to recommend or endorse any specific products.

How Does the Liver Work? - Informedhealth.org - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK279393/.

Physiology, Liver - Statpearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK535438/.

“Liver: Anatomy and Functions.” Liver: Anatomy and Functions | Johns Hopkins Medicine, 19 Nov. 2019, https://www.hopkinsmedicine.org/health/conditions-and-diseases/liver-anatomy-and-functions#:~:text=Functions%20of%20the%20liver,intestines%20passes%20through%20the%20liver.

“5 Ways to Be Kind to Your Liver.” 5 Ways to Be Kind to Your Liver | Johns Hopkins Medicine, 18 Oct. 2021, https://www.hopkinsmedicine.org/health/wellness-and-prevention/5-ways-to-be-kind-to-your-liver#:~:text=%E2%80%9CYour%20liver%20removes%20all%20toxins,it%20and%20regulates%20hormone%20levels.

Du S;Wang C;Jiang W;Li C;Li Y;Feng R;Sun C; “The Impact of Body Weight Gain on Nonalcoholic Fatty Liver Disease and Metabolic Syndrome during Earlier and Later Adulthood.” Diabetes Research and Clinical Practice, U.S. National Library of Medicine, https://pubmed.ncbi.nlm.nih.gov/27321334/. 

Kurt Grüngreiff *, et al. “The Role of Zinc in Liver….” Annals of Hepatology, Elsevier, 1 Jan. 2016, https://www.sciencedirect.com/science/article/pii/S1665268119307355. 

Milk Thistle (PDQ®) NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK65780/. 

Rashed ZE;Grasselli E;Khalifeh H;Canesi L;Demori I; “Brown-Algae Polysaccharides as Active Constituents….” Planta Medica, U.S. National Library of Medicine, https://pubmed.ncbi.nlm.nih.gov/33142346/. 

Naeini F;Zarezadeh M;Mohiti S;Tutunchi H;Ebrahimi Mamaghani M;Ostadrahimi A; “Spirulina Supplementation as an Adjuvant Therapy in Enhancement of Antioxidant Capacity: A Systematic Review and Meta-Analysis of Controlled Clinical Trials.” International Journal of Clinical Practice, U.S. National Library of Medicine, https://pubmed.ncbi.nlm.nih.gov/34235823/. 

Bustamante J;Lodge JK;Marcocci L;Tritschler HJ;Packer L;Rihn BH; “Alpha-Lipoic Acid in Liver Metabolism….” Free Radical Biology & Medicine, U.S. National Library of Medicine, 

White, C Michael, and Ji-Young Lee. “The Impact of Turmeric or Its Curcumin Extract…: A Systematic Review of Clinical Trials.” Pharmacy Practice, U.S. National Library of Medicine, 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463416/. 

• Less Than 100mg of Milke Thistle (Silymarin): Milk thistle is a common ingredient across many different liver health supplements due to its antioxidant support. You may want to look for a formula that contains more than 100mg. 
• Missing Safety Testing & Certifications: Choose a supplement that has been independently third-party lab tested and manufactured in the USA. These precautions will guarantee that the product is top quality and free from unwanted extras, such as contaminants, traces of heavy metals, or pesticides.
• Suspiciously Cheap Products: When it comes to your health, this is definitely not an area to test out suspiciously cheap products. There are plentiful options to choose from that are high-value and still affordable. In this case, you do get what you pay for!

• Vitamin E: This is a potent antioxidant that supports oxidative stress. Antioxidants support liver health by maintaining balance in the liver. 
• Zinc: Studies suggest zinc deficiency may impact liver regeneration. The liver is the main organ responsible for zinc metabolism.[7] 
• Milk Thistle: The active substance in milk thistle is silymarin. Studies suggest silymarin may help to support healthy liver tissue, support comfort, and potentially provide antioxidant support to liver cells.* [9] 
• Selenium: Selenium is an essential trace element with powerful antioxidant properties, which may be beneficial for liver health support.
• Algae: Members of the algae family such as brown seaweed, spirulina (blue-green algae), and chlorella are antioxidant and vitamin-packed. Brown seaweed, for example, has been suggested to support liver fat overgrowth. Reducing fat around the liver may help support healthy liver function.*[8, 9]
• Amino Acids: Amino acids like L-cysteine and L-glutathione help to break down the food further and are also a great source of antioxidants. 
• Alpha Lipoic Acid: Alpha-lipoic acid is an antioxidant that is made in the body and is also found in foods such as spinach, beets, and potatoes. It is used to break down carbohydrates and to make energy. Research suggests that ALA may be effective in supporting liver health.* [10] 
• Curcumin: Curcumin is the main active compound in turmeric which has been used for centuries in Ayurveda.  Some studies have suggested curcumin may support healthy liver enzyme function.* [11]