Best Gut Health Supplements 2025

Immune 

health

It All Starts In Your Gut

Bloating, constipation, indigestion

Common Ingredients In Gut Support Supplements

Top 5 Gut Supplements Of 2025

Key Ingredients To Look For

Elements To Look Out For

Important Criteria

Prebiotics

Probiotics

Postbiotics

No Refrigeration Required

Bio Complete 3 by GundryMD

Zupoo by UMZU

60 Billion Probiotic by Physician's Choice

Once upon a time, the digestive system was widely viewed as a pretty simple and straightforward system in our body… But if you’ve ever experienced gut-related issues, you already know that can be anything but simple… In fact, getting to the root cause of gut and gut-related symptoms can very quickly become an incredibly frustrating and confusing process.

Whenever you see the term “gut microbiome,” it’s referring to all of the microorganisms living within your gut. Some of them may be potentially harmful, so-called “bad” bacteria. On the other hand, some are thought to be beneficial, often called “good” or “friendly” bacteria.[1, 2, 3, 4] 

Researchers believe that having optimal gut health typically means having a good balance between the “bad” bacteria and the “good’ bacteria. Ideally, they should co-exist peacefully within the gut.[1, 2, 3, 4] 

Acne or other skin issues

Brain fog and 

mood 

What Exactly Is Your Gut Microbiome?

Our Choice

• USA-made with globally sourced ingredients
• Third-Party Lab-Tested
• 3-in-1 Gut Formula 
• 90-Day Money-Back Guarantee
• Pre-, Pro-, and Postbiotics

Based on 3739 Reviews of Primal Harvest 

90-Day Money-Back Guarantee

Subscription Service

Third-Party Lab-Tested 

Bloating, constipation, indigestion? Acne or other skin issues? It may be stemming from your gut. Feeling run down and sluggish? It could also be related to your gut.[1, 2, 3] 

Researchers have become increasingly interested in exploring the gut and its role in so many major areas of our health. But it seems like we’re only just beginning to scratch the surface when it comes to truly understanding the immensely complex connection between gut microbiome health and its impact on our overall well-being.[1, 2, 3] 

Promoting a balanced gut bacteria, aka microbiome*

How To Support Your Gut Health

Helping us digest our food better*

Changing your diet, sleeping more, avoiding stressful situations, exercising and avoiding sugar might sound simple but aren't always as easy to follow through with. 

That's why some people may turn to supplements such as probiotics and prebiotics to support their gut health.* Some potential benefits of probiotics and prebiotics include:

Supporting overall gut health*

Probiotics + Prebiotics = Postbiotics

Haven’t heard of postbiotics? You’re most definitely not alone. A fairly new term in the health and wellness world, researchers have recently begun exploring the potential of postbiotics when it comes to supporting the gut.

Postbiotics are what’s created when “good” gut bacteria feeds on prebiotic fibers. In other words, prebiotics + probiotics = postbiotics.

Postbiotics are what’s left at the end, once the “good” bacteria has fed on fiber (prebiotics). They include a number of substances and nutrients such as amino acids, vitamins, as well as short-chain fatty acids. 

Short-chain fatty acids are a particularly interesting type of postbiotic because they are thought to contribute to supporting gut health. This is because studies suggest that they can help the “friendly” bacteria flourish in the gut. One of the most prevalent of these is called butyrate, which is believed to support both gut and intestinal health.*

There are plenty of gut health supplements on the market today that promise to restore the balance of your gut. Yet it can be difficult to navigate an overwhelming variety of supplements and their ingredients. Knowing what to look for and what to try to avoid can help you make an informed decision when shopping for a gut supplement. 

Try To Avoid...

Note: We try to update product information as often as we can. Please visit product websites for more information.

Why Is The Gut Microbiome Important?

The gut microbiome plays so many essential roles in the human body, it’s sometimes referred to as “a supporting organ”. It can affect many aspects of health, ranging from the gut to the immune system to brain health.[3] 

Everyone’s gut microbiome is entirely unique and can be impacted by things like diet and our surrounding environment.[5]

It’s likely that our modern lifestyles may have been wreaking havoc on our gut microbiota for years. Eating more processed and sugary foods, experiencing more stress, sleeping less, and being more sedentary, can all contribute to imbalance in the gut microbiome.[1, 2, 3, 4]  

• Formulated with CoreBiome™️ Tributyrin postbiotics
• Contains 3 bill. CFUs of B. Longum BB536® probiotics
• Made with pre, pro, and postbiotics
• Third-party lab-tested
• USA-made with globally sourced ingredients 
• 90-day Money-Back-Guarantee

PROS

CONS

• Only available online
• Sometimes runs out of stock

Gut Restore by Primal Harvest is an all-in-one gut support formula that contains pre-, pro- and postbiotics. It is formulated with the trademarked CoreBiome™️ tributyrin postbiotic, 3 billion CFUs of B. Longum BB536® probiotics, and xyliooligosaccharide prebiotics. The capsules are easy to swallow and liked the two-capsule serving size as it made it easy to add to our supplement routine. All in all, you may feel that this product offers everything you are looking for in a gut supplement, making it your favorite from the products you have tried.

Additionally, the formula is third-party lab-tested and made in the USA with globally sourced ingredients. To top it off, they’re backed by a 90-day money-back guarantee. You may notice that the product was fairly priced, especially when you buy multiple bottles or sign up for the brand’s easy and convenient subscription service. 

BOTTOM LINE

A+

GRADE

2. Bio Complete 3

by GundryMD

PROS

• Contains pre & probiotics
• 90-day money-back guarantee
• Doctor-formulated

CONS

• Glass bottle
• Does not note if it is a gelatin or vegetable capsule

BOTTOM LINE

Bio Complete 3 by GundryMD contains a blend of pre, pro, and postbiotics. While this product has a comprehensive formula, the serving size is 2 capsules to take each day. You may also want to note that at $69.95, this option is a little pricier than some of the others on this list.

B+

GRADE

4. Bye Bye Bloat

By Love Wellness

PROS

• Blend of digestive enzymes and organic herbs
• Non-GMO, gluten-free, and dairy-free
• Many organic ingredients

CONS

• No direct probiotics or postbiotics
• 30-day money-back guarantee (shorter than some competitors)

BOTTOM LINE

Bye Bye Bloat by Love Wellness combines digestive enzymes with organic herbs like fenugreek, dandelion, and fennel, which may have prebiotic effects. The product is free from artificial additives and contains many organic ingredients. While it offers a natural approach to digestive health, it lacks direct probiotics and postbiotics found in some other gut health supplements. The 30-day money-back guarantee is shorter than some top-ranked competitors. Overall, it's a decent option for those seeking relief from occasional digestive discomfort, particularly if you're looking for a blend of enzymes and potential prebiotic herbs.

C+

GRADE

3. 60 Billion Probiotic

by Physician's Choice

PROS

• Contains pre- and probiotics 
• 10 diverse probiotic strains 
• Non-GMO verified

CONS

• No postbiotics
• Not formulated with trademarked strains (unlike other competitors on this list)

BOTTOM LINE

60 Billion Probiotic by Physician's Choice offers a combination of prebiotics and probiotics, with a high CFU count and 10 bacterial strains. While it contains beneficial ingredients like organic Jerusalem artichoke and chicory root for prebiotic support, it lacks added postbiotics.

The formula sticks to standard probiotic strains rather than the premium patented strains seen in top competitors. Though it's made to high quality standards with Non-GMO verification, you may find better value in products that offer a more complete pre-, pro-, and postbiotic formula. Still, if you're specifically looking for a high-CFU probiotic supplement with decent prebiotic support, this could be worth considering.

B

GRADE

5. Zupoo

by UMZU

PROS

• Chemist-formulated
• Variety of ingredients
• Two capsule serving size
• Produced in a CGMP facility 

CONS

• No pre-, pro-, or postbiotics
• Price (only a 15-day supply)

BOTTOM LINE

Zupoo by UMZU is formulated with extracts including Cascara Sagrada, bentonite clay, aloe ferox, milk thistle, and cayenne pepper extract. The product contains sustainably sourced ingredients and is produced in a CGMP-certified facility, it does not contain any probiotics, prebiotics, or postbiotics. Additionally, it is fairly expensive when considering that one bottle only contains a 15-day supply. 

B

GRADE

Support healthy regularity*

Support digestive concerns*

1. Integrative HMP (iHMP) Research Network Consortium. “The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health….” Cell host & microbe vol. 16,3 (2014): 276-89. doi:10.1016/j.chom.2014.08.014

2. Sender, Ron et al. “Revised Estimates for the Number of Human and Bacteria Cells in the Body.” PLoS biology vol. 14,8 e1002533. 19 Aug. 2016, doi:10.1371/journal.pbio.1002533

3. Durack, Juliana, and Susan V Lynch. “The gut microbiome… opportunities for therapy.” The Journal of experimental medicine vol. 216,1 (2019): 20-40. doi:10.1084/jem.20180448

4. Al Bander, Zahraa et al. “The Gut Microbiota…An Overview.” International journal of environmental research and public health vol. 17,20 7618. 19 Oct. 2020, doi:10.3390/ijerph17207618

To see a list of our other references, please click here. 

CITATIONS

DISCLAIMER: This scientific research is for informational purposes only. The results reported may not necessarily occur in all individuals. Primal Harvest provides this information as a service but does not endorse it. This information should not be read to recommend or endorse any specific products.

• Uncertain CFU count - CFUs, or colony-forming units, are a method of counting how much live bacteria is in a probiotic product. The amount of CFUs can vary from product to product and can change from 1 to 10 billion (though more is not always better).*
• Lack of Third-Party Testing - Always look for ‘third party lab-tested’ verifications that guarantee the product has been independently tested for any heavy metals, bacteria, pesticides, or traces of any other harmful substances. This helps to ensure safety and efficacy of the product.* 
• Extremely Low or High Price - Do your research before buying an overpriced or suspiciously cheap supplement. Do not cut corners for your gut health.

• Probiotics – Probiotics are “good” bacteria and yeasts, thought to benefit the digestive system by helping to maintain gut balance. There are many different strains of probiotics.*
• Prebiotics – Prebiotics are a form of dietary fiber that acts as a source of food for the “good” bacteria in your gut.*
• Synbiotics  – Synbiotics are a combination of probiotics and prebiotics, their name comes from the fact that they create synergy between probiotics and the specific fiber they need to feed on.*
• Postbiotics – Postbiotics are the “waste” product of probiotics feeding on prebiotics. They are bioactive compounds like short-chain fatty acids, that are associated with a number of health benefits.*
• Digestive enzymes – Digestive enzymes play a key role in breaking down the food you eat.*

Bye Bye Bloat By Love Wellness

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