Primal NAD+ stands out for being the only formula on this list to combine CoQ10 with research-backed doses of Nicotinamide Riboside and Trans-Resveratrol, three of the most effective and well-studied nutrients for supporting cellular energy, healthy aging, and antioxidant protection.

We especially liked the addition of Betaine, which supports DNA repair and methylation, further enhancing the body’s ability to utilize NAD+ precursors.

Of all the products we reviewed, none offered such a well-rounded combination at such effective doses. The simple 2-capsule serving makes it easy to stay consistent, and it’s backed by a 90-day money-back guarantee, an industry gold standard. While it may not be widely available in stores, Primal NAD+ is our top pick for the best CoQ10 and NAD+ supplement of 2025.

What To Look For in a CoQ10 Supplement

Try To Avoid

Try To Look For:

Important Criteria

NAD+ by Life Extension

NiaCel 400

by Thorne

90-Day Money-Back Guarantee

Third Party Tested

Subscription Service

*Based on the individual experience of the Smarter Choices team and on a number of user reviews of the product. 

Note: We try to update product information as often as we can. Please visit product websites for more information. 

PROS

• 300 mg NR per serving
• With Trans-Resveratrol
• Competitive returns policy

CONS

• Features proprietary blends
• Trans-Resveratrol dose (10 mg) falls well under recommendations

BOTTOM LINE

NAD+ by Life Extension provides 300 mg of NR per serving and includes Trans-Resveratrol, though the 10 mg dose is far below the recommended 250 mg minimum. The formula also relies on proprietary blends, which add unnecessary complexity and limit transparency. Most importantly, it does not include CoQ10. While it does come with a one-year return policy, opened products may not be eligible.

C+

GRADE

PROS

• 300 mg NR per serving
• 1-capsule serving size
• No artificial colors

CONS

• 30-day returns window
• Lacks additional support, such as CoQ10, for healthy aging

BOTTOM LINE

Tru Niagen delivers a convenient 1-capsule serving with 300 mg of NR and, like all products on this list, contains no artificial colors or flavors. Unfortunately, its 30-day return window is the shortest here, and it again lacks CoQ10 or other supporting ingredients that enhance cellular energy and healthy aging. While it’s a viable choice for straightforward NAD+ support, other options on this list provide more comprehensive formulas—and better overall value.

B

GRADE

by Renue By Science

PROS

• High dose of NR per serving 
• Non-GMO
• Made in a GMP compliant facility

CONS

• No CoQ10
• No Trans-Resveratrol 

BOTTOM LINE

Nicotinamide Riboside by Renue By Science is a good option for those who want a high dose of NR and no additional support for healthy aging and cellular longevity. Unfortunately, it leaves out any other key nutrients for well-rounded support - most notably CoQ10. 

B+

GRADE

PROS

• 415 mg NR per serving
• With Betaine
• 60-day returns policy

CONS

• No CoQ10
• Betaine dose inferior to top pick

BOTTOM LINE

NiaCel 400 by Thorne is a solid choice from a trusted brand, backed by a 60-day return policy. It provides a meaningful dose of NR and includes 85 mg of betaine to support DNA repair—though this is far below the amount in our top pick (which offers over five times more). The biggest drawback, however, is that it doesn’t include CoQ10, a key nutrient for mitochondrial energy and antioxidant protection. 

C

GRADE

PROS

CONS

• May not be as widely available in retail stores as larger brands

BOTTOM LINE

A+

GRADE

• Supports healthy aging and cellular longevity*
• 100 mg Coenzyme Q10 (Ubiquinone)
• 425 mg Nicotinamide Riboside Chloride (NR) per serving (recommended dose)
• 425 mg Trans-Resveratrol 
• With 300 mg Betaine (Trimethylglycine) and 100 mg Coenzyme Q10 (Ubiquinone)
• Convenient 2-capsule serving size
• Made in a GMP compliant facility
• 90-day money-back guarantee

DISCLAIMER: This scientific research is for informational purposes only. The results reported may not necessarily occur in all individuals. Primal Harvest provides this information as a service but does not endorse it. This information should not be read to recommend or endorse any specific products.

Trammell, S. a. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 7(1). https://doi.org/10.1038/ncomms12948

Damgaard, M. V., & Treebak, J. T. (2023). What is really known about the effects of nicotinamide riboside supplementation in humans. Science Advances, 9(29). https://doi.org/10.1126/sciadv.adi4862

Yang, X., Lu, A., Guan, X., Ying, T., Pan, J., Tan, M., & Lu, J. (2024). An updated review on the mechanisms, Pre‐Clinical and clinical comparisons of nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). Food Frontiers. https://doi.org/10.1002/fft2.511

Dellinger, R. W., Santos, S. R., Morris, M., Evans, M., Alminana, D., Guarente, L., &

Marcotulli, E. (2017). Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. Npj Aging and Mechanisms of Disease, 3(1). https://doi.org/10.1038/s41514-017-0016-9

CITATIONS

Our Choice 2025

2. Nicotinamide Riboside

5. Tru Niagen

4. NAD+

by Life Extension

3. NiaCel 400

Based on 3739 Reviews of Primal Harvest

CoQ10: what is it?

Although it’s often referred to as the “Q10 vitamin”, CoQ10 isn’t actually a vitamin, as the body manufactures it itself. 

CoQ10 is often promoted for its potential to support healthy aging, primarily due to its ability to help protect cells from oxidative stress and support energy production. It has been shown to help maintain skin resilience and reduce some visible signs of aging. CoQ10 also supports overall cellular health and energy, which can contribute to maintaining wellness as the body ages.

Nicotinamide Riboside by Renue By Science

​

Tru Niagen

• With CoQ10 and NR to support healthy aging and cellular longevity*
• US-Made with Globally Sourced Ingredients
• Made in GMP facility and Third-Party Tested
• 90-Day Money-Back Guarantee

Top CoQ10

Supplements in 2025

Most people searching for a CoQ10 supplement want more energy, healthy aging support, or help replenishing levels that may decline with age or statin use. But while CoQ10 (ubiquinone/ubiquinol) helps your cells use energy efficiently, your body also needs NAD+ (nicotinamide adenine dinucleotide) to make that energy in the first place.

That’s why our panel didn’t just look at the best CoQ10 supplements: we also considered which products combine Coenzyme Q10 with NAD+ precursors. This pairing supports both sides of the energy equation, helping protect cells from oxidative stress while also fueling them at the source.

Spoiler: only one product on our list includes both CoQ10 and NAD+ precursors.

by Thorne

Try To Avoid

No Artificial Sweeteners

Why Do People Take CoQ10 Supplements?

Replenishing levels that may decline with statin use*

Many people look to CoQ10 for:

Supporting energy production in cells*

Who Should Consider a CoQ10 Supplement?

• Adults over 30: Natural CoQ10 levels begin to decline around this age, so supplementation may help maintain adequate levels.
• People taking statins: Statin use can lower CoQ10 levels, and some take supplements to replenish them, potentially easing muscle symptoms associated with statins.
• Those looking for cardiovascular support: CoQ10 is well-studied for aiding heart health and improving symptoms in some heart conditions.
• Anyone interested in antioxidant and healthy aging support: CoQ10’s antioxidant properties and role in cellular energy support are reasons many seek it for overall vitality and healthy aging.

Supporting overall vitality as we age*

Acting as a powerful antioxidant*

Helping maintain cardiovascular health*

But with so many options on the market, it can be hard to know which coenzyme q10 supplement is best.

CoQ10 may support the aging process by protecting cells and maintaining energy levels. It may help people maintain vitality and cellular function. While your body produces CoQ10 naturally, levels decline with age. That’s why many people turn to a CoQ10 dietary supplement.

CoQ10 (Coenzyme Q10)

Nicotinamide Riboside Chloride (NR)

Trans-Resveratrol

HPMC Capsules: 

• Coenzyme Q10: A key antioxidant supporting cellular energy production. Often combined with NAD+ precursors for extra benefit. Recommended dose: 100–200 mg daily.
• Nicotinamide Riboside Chloride (NR): A well-researched NAD+ precursor that supports cellular energy. Recommended dose: 250–500 mg daily.
• Trans-Resveratrol: Supports cellular health and may enhance NAD+ activity. Recommended dose: 250–500 mg daily.
• Hypromellose (HPMC) Capsules: Plant-based capsules that support ingredient stability and absorption.
• Third-Party Testing: Ensures purity and quality.

• Unproven Precursors: Choose NAD+ precursors like Nicotinamide Riboside (NR) that are well-studied and shown to work synergistically with Coenzyme Q10 (CoQ10). This can reduce the risk of wasting money or unknown health risks.
• Overly Complex Formulas: Aim for supplements with 2 to 5 key ingredients, focusing on a primary NAD+ precursor and supporting nutrients rather than long lists of fillers or untested additives.
• Supplements with Unclear or Proprietary Blends: Avoid products that don’t clearly list all ingredients and their amounts. Proprietary blends can hide underdosed or unnecessary additives.
• Under- or Over-Dosed Products: Follow recommended doses backed by research to ensure the supplement is effective and minimize any potential side effects.