Top 5 Cognitive Enhancement Supplements of 2025

Our Choice

Primal Mind Fuel

• CogniPlex™ B Vitamins
• NeuroSmart™ Cognitive Enhancement Blend
• 1 Capsule Per Day
• Made in the USA with globally sourced ingredients
• Free Shipping on Orders Over $75

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Based on 3739 Reviews of Primal Harvest

What To Try To Avoid In Your Cognitive Support Supplement*

by Stonehenge

PROS

• Includes B vitamins and Bacopa monnieri
• Third-party tested
• 90-day money-back guarantee

CONS

• Contains fish and soy
• 2-capsule serving size

BOTTOM LINE

Dynamic Brain by Stonehenge consists of a wide variety of ingredients, including amino acids, adaptogens, vitamins, and minerals. It contains 60 capsules, or a one-month supply, taken as a 2-capsule serving. It features some common go-to ingredients such as huperzine A and Bacopa monnieri and is third-party tested. It comes in a veggie capsule, but those with specific dietary needs should note that the product does contain fish and soy. 

3. Dynamic Brain

PROS

• Includes a blend with Bacopa monnieri, huperzine A, and more
• Vitamins and minerals
• Third-party lab tested

CONS

• Contains fish
• 4-tablet serving size
• 7-day return policy

BOTTOM LINE

This brain supplement by FF contains a variety of vitamins and minerals such as vitamins A, B6, C, D, and E, zinc, iron, magnesium, and calcium. It features a variety of B vitamins and plant-based extracts and is both vegan-friendly and GMP-certified. However, the 2-4 capsule serving size might be inconvenient to take for some people. When purchased directly from the website, a one-month supply will set you back $69.00 which places this formula at the higher end of the price range in comparison to the other products included on this page. 

2. Alpha Brain

by Onnit

PROS

• Includes B vitamins, l-tyrosine, l-theanine, and extracts
• Third-party tested
• 90-day money-back guarantee

CONS

• 2-capsule serving size
• 15 servings per container

BOTTOM LINE

Alpha Brain by Onnit is formulated with vitamin B6 as well as Onnit’s own Onnit Flow Blend, Onnit Focus Blend, and Onnit Fuel Blend. 

The formula comes in vegetarian capsules with a serving size of 2 capsules per day. The capsules are free of gluten and dairy and are third-party tested. The product contains a good range of ingredients in the formula, however, the price may be considered high since it only contains 15 servings per container.

Primal Mind Fuel by Primal Harvest features a premium blend of B vitamins and cognitive enhancers. Expertly formulated, it combines CogniPlex™ B vitamins (with vitamins B6, B12, and B1) with a NeuroSmart™ Blend that features rhodiola, Bacopa monnieri, l-tyrosine, theobromine, huperzine A, and D-glucuronolactone. 

This brain-boosting formula delivers premium ingredients in a convenient once-daily serving. As all high-quality supplements should be, Primal Mind Fuel is third-party lab tested and made in the USA with globally sourced ingredients. The product offers great value for money and the brand has a convenient Subscribe & Save program which means you can order this formula through their convenient and hassle-free subscription service. By signing up for a subscription you get 20% off all products plus free shipping. ​

To top it off, Primal Harvest has excellent customer service scores and a 90-day money-back guarantee. 

• CogniPlex™ B vitamins
• NeuroSmart™ cognitive enhancement blend
• 1 capsule per day
• 90-day money-back guarantee
• Certified safety and purity testing 
• Made in the USA with globally sourced ingredients

PROS

CONS

• Only available online
• Due to high demand, sometimes runs out of stock

BOTTOM LINE

A+

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B+

GRADE

B

GRADE

C

GRADE

What to Look For In A Cognitive Support Supplement*

Many of us experience times when our concentration, stress resistance, or mental performance could use a little extra support. It’s no wonder that cognitive enhancement supplements have become hugely popular in the last few years. 

Many factors can cause a lag in cognitive performance, from daily stress, age, and lifestyle habits to dehydration and poor nutrition. 

Choosing the right supplement can be tricky, especially when there are so many choices out there. Read on to find out more about key ingredients, what to look for, and what to avoid, plus discover our top picks for the best cognitive enhancement supplements of 2025. 

What Are Cognitive Enhancement Stacks?

Because of their complex nature, cognitive supplements are usually sold separately. However, it is possible to conveniently combine these ingredients into a single formula in what is known as a “stack.”

A stack is a blend of several ingredients that work together in a complimentary way to support cognitive performance.*

1. Primal Mind Fuel

Potential Benefits of Cognitive Support Supplements*

Whether they're looking to support energy, stress, mental agility, or just their general cognitive well-being, some people choose to turn to high-quality cognitive supplements thanks to the convenience they offer.*

It’s always important to consult with your personal physician before starting a new supplement routine.

Top Ingredients in Cognitive Supplements

There are certain ingredients that are popular in these types of cognitive support supplements. The ones to look for include:

*Individual results may vary

Potential Drawbacks of Some Cognitive Support Supplements

Unfortunately, some generic cognitive support supplements may not satisfy your needs or expectations.

Here are some factors you may want to try to avoid when choosing your cognitive support supplement:

5. Brain Supplement

by FF

• Unclear Labels:  A quality supplement should clearly list exactly what’s included in the formula. It’s generally best to avoid products lacking transparency that don’t list all of the specific ingredients included in the formula’s cognitive blend.
• Missing Safety Testing & Certifications: Choose a cognitive support supplement that has been independently third-party lab tested and manufactured in the USA. These precautions will guarantee that the product is top quality and free from unwanted extras, such as contaminants, traces of heavy metals, or pesticides. *
• False or Misleading Claims: Beware of any cognitive supplements that claim their product treats or cures any specific health issues or ailments, or promises miraculous results. Always speak to your doctor before starting a new supplement routine.*
• Suspiciously Cheap Products: When it comes to your cognitive health, this is definitely not an area to test out suspiciously cheap products. There are plentiful options to choose from that are high value and still affordable. In this case, you do get what you pay for!
• Apoaequorin (Jellyfish Protein): Among some of the many trendy memory boosters, Apoaequorin is a protein made by certain luminescent jellyfish that is found in some cognitive support supplements.

To see a list of our references, please click here. 

CITATIONS

DISCLAIMER: This scientific research is for informational purposes only. The results reported may not necessarily occur in all individuals. Primal Harvest provides this information as a service but does not endorse it. This information should not be read to recommend or endorse any specific products.

• Rhodiola Rosea: Historically used as a remedy for centuries in Russia, Europe, and Asia, rhodiola is an adaptogen that may help support stress, mood, motivation, and fatigue.*
• Caffeine: One of the most popular cognitive enhancers, caffeine creates an energizing effect (which is why many choose to start the day with a cup of Joe).  Caffeine may help support energy, focus, attention, mood, and athletic performance.*
• L-Tyrosine: L-Tyrosine is an amino acid used by the brain for a number of functions. This amino acid has the potential to support mental performance during high-stress situations and fatigue, as well as to support mood, concentration, and motivation.*
• Vitamin B: B vitamins, including B1, B6, B9, and B12, are considered important for maintaining brain health and energy (amongst other things). They may also help support mental clarity, energy production, and focus.*
• Bacopa Monnieri: Bacopa monnieri is an antioxidant-rich herb that has been traditionally used for centuries in Traditional Chinese health practices and Ayurveda to support memory, stress, and potentially support learning.*

What To Look For

What To Avoid

Important Criteria

Rhodiola Rosea

Caffeine

L-Tyrosine

Huperzine A

B Vitamins

Bacopa Monnieri

90-Day Money-Back Guarantee

Third-Party Tested

Subscribe & Save Program

Brain Supplement by FF

Alpha Brain by Onnit 

Dynamic Brain by Stonehenge

Neuriva Original by Neuriva

No Apoaequorin

Top Cognitive Support of 2025

*We try to update product information as often as we can. Please visit product websites for more information.

4. Neuriva Original

by Neuriva

PROS

• Simple one-capsule daily serving 
• Vegetarian and Gluten-Free

CONS

• Contains soy (potential allergen)
• Limited to only two main active ingredients

BOTTOM LINE

Neuriva Original is a brain supplement that focuses on two main ingredients: Neurofactor (coffee fruit extract) and Phosphatidylserine. It claims to support various aspects of cognitive function, including memory and focus. The product offers a convenient one-capsule daily serving. However, the formula is limited to just two primary active ingredients, which may not be as comprehensive as other options on the market. Additionally, the presence of soy could be a concern for those with allergies or sensitivities. While some users report positive effects, the relatively high price point for a two-ingredient formula may not offer the best value compared to more complex cognitive support supplements.

C+

GRADE