Types of Toxins

What Are Toxins?

Anything that we eat, drink, inhale, or place on our skin eventually makes its way into our bloodstream, where it then needs to be processed by our bodies (especially by the liver, colon, and kidneys).

Toxins, in the general sense, are waste products that your body cannot fully eliminate through digestion or other means.

Note: Individual results may vary.

Cellular waste products

Also known as metabolic waste [4]

Environmental

Like those found in air pollution, household products, and cosmetics [3]

Bacteria from the digestive tract

Bacterial toxins that can form in your digestive tract [5]

Toxins May Impact the Body by Affecting...

• Healthy hormone function and balance*
• Enzyme function*
• Nutrient absorption which may cause deficiencies*
• Oxidative stress in the body*
• Gut health which may lead to gut issues*

And more...

What To Try To Avoid In Your Cleanse & Detox Supplement

Popular Ingredients in Cleanse & Detox Supplements:

by ColonBroom

PROS

• ColonBroom app
• Blended in the USA

CONS

• Price
• Contains 20 calories
• Precise timing of consumption

BOTTOM LINE

Colon Broom is a water-soluble powder supplement that is intended to be taken 1-2 times per day 30 minutes before a meal with an extra glass of water. Each scoop delivers 3.6 g of psyllium husk powder, the formula’s primary ingredient. This product provides 3 g of fiber and is manufactured in a GMP-certified facility. However, each serving also contains 20 calories as well as 60 mg of sodium. This formula may not be as easy to implement into a daily routine as some others, as it is recommended to be consumed about half an hour before a meal and must be drunk immediately otherwise thickening may occur, according to the consumption instructions provided. 

C+

GRADE

4. Colon Broom

3. Daily Cleanse

By HUM

PROS

• Includes minerals
• Formulated with plant extracts
• Third-party tested

CONS

• 30-day return policy
• No L. acidophilus

BOTTOM LINE

Daily Cleanse by HUM features ingredients like spirulina, chlorella, milk thistle, and beet root powder. Although it's formulated without probiotics, HUM’s Daily Cleanse does include the minerals zinc and selenium and comes in a 2-capsule per day serving. While it's fairly priced, some may want to note that it only comes with a 30-day return policy.

B

GRADE

• Formulated with herbal extracts, fiber, and antioxidants 
• Includes the probiotic L. acidophilus
• 2-capsule serving size
• 90-day money-back guarantee  
• Made in the USA with globally sourced ingredients
• Third-party lab tested

PROS

CONS

• Only available online
• Due to popularity, sometimes runs out of stock

Primal Total Cleanse by Primal Harvest features a varied blend of herbal extracts, antioxidants, fiber, and probiotics. It features a blend of ingredients like acai berry, fennel seeds, aloe vera leaf, senna leaf, cascara sagrada, ginger, flaxseed, oat bran, and Lactobacillus acidophilus. It contains all of this and more in just two capsules per day.

As all high-quality supplements should be, Primal Total Cleanse is third-party lab tested and made in the USA with globally sourced ingredients. The product offers great value for money and comes with a 90-day money-back guarantee. The brand has a convenient Subscribe & Save program which means you can order this formula through their convenient and hassle-free subscription service. By signing up for a subscription you get 20% off all products plus free shipping. 

BOTTOM LINE

A+

GRADE

CITATIONS

What To Look For

Try To Avoid

Important Criteria

Natural Colon Cleanse by The Enclare 

Daily Cleanse by HUM

Colon Broom by ColonBroom

ZuPoo by UMZU

Top Gut Cleanse Supplements 2025

Fennel Seed

Aloe Vera Leaf

Lactobacillus Acidophilus

Senna Leaf

Cascara Sagrada

Oat Bran Fiber

Licorice Root

Acai Berry

No Japanese Star Anise

2. Natural Colon Cleanser

PROS

• Herbal blend 
• Includes probiotics
• Made in the USA

CONS

• No 90-day money-back guarantee
• No subscription program

BOTTOM LINE

Natural Colon Cleanser by The Enclare is formulated with a herbal blend and probiotics and is made in the USA. It contains ingredients like senna leaf, cascara sagrada, psyllium husk, licorice root, and L. acidophilus. However, the brand does not offer a 90-day money-back guarantee or a subscription program. 

B+

GRADE

by The Enclare

Our Choice

• USA-made with globally sourced ingredients
• Contain herbs, fiber, and probiotics
• Easy-to-take capsules
• Made in the USA with globally sourced ingredients
• Free shipping on orders over $75

Based on 3732 Reviews of Primal Harvest 

5. ZuPoo Gut Support 

by UMZU

PROS

• Features cascara sagrada, fennel seed, and senna leaf 
• Taken once daily before bed
• Made in a CGMP facility 

CONS

• No probiotics
• Only a 15-day supply 

BOTTOM LINE

ZuPoo Gut Support by UMZU features ingredients like cascara sagrada, fennel seed, and senna leaf. While this product features herbs, it does not contain probiotics. It is relatively easy to add to a routine, as users are instructed to take 2 capsules before bed once a day. That being said, some may want to note the price of the product and that it only contains a 15-day supply.

C

GRADE

DISCLAIMER: This scientific research is for informational purposes only. The results reported may not necessarily occur in all individuals. Primal Harvest provides this information as a service but does not endorse it. This information should not be read to recommend or endorse any specific products.

1. “Fact Sheet: Potentially Toxic Chemicals in Personal Care Products.” New York Health Foundation, 7 Mar. 2019, https://nyhealthfoundation.org/resource/fact-sheet-potentially-toxic-chemicals-in-personal-care-products/. 

2. Allen J, Montalto M, Lovejoy J, Weber W. Detoxification…: a survey. J Altern Complement Med. 2011;17(12):1175-1180. doi:10.1089/acm.2010.0572. 

3. Crinnion WJ. Environmental medicine, part one: the human burden of environmental toxins and their common health effects. Altern Med Rev. 2000;5(1):52-63.

4. “Metabolic Waste.” Metabolic Waste - an Overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/medicine-and-dentistry/metabolic-waste. 

5. Pizzorno, Joseph. “Toxins From the Gut.” Integrative medicine (Encinitas, Calif.) vol. 13,6 (2014): 8-11.

6. Madden GR, Schmitz KH, Fullerton K. A case of infantile star anise toxicity. Pediatr Emerg Care. 2012;28(3):284-285. doi:10.1097/PEC.0b013e3182495ba7

To see a list of our other references, please click here. 

Note: We try to update product information as often as we can. Please visit product websites for more information.

• Fennel Seed: Rich in both antioxidants and fiber, fennel seeds may help support relaxed digestion, metabolism, and occasional gas.*  
• Aloe Vera Leaf: Rich in phytonutrients, aloe vera has been historically used for centuries for its cleansing and antioxidant properties that help support healthy detoxification.*
• Lactobacillus Acidophilus: Research suggests that certain probiotics, for example, Lactobacillus acidophilus, may support gut health, digestion, and comfortable regularity.*
• Senna Leaf: Originally from Egypt, this herb has been used to support digestion, occasional constipation, gas, and bloating.*
• Cascara Sagrada: Cascara sagrada has traditionally been used to support healthy digestion, occasional constipation, and bloat.* 

Note: These statements are not intended to diagnose, treat, cure, or prevent any disease or condition, nor are they intended to be substitutes for professional medical health advice. Always consult your physician or other qualified healthcare provider for accurate advice, diagnosis, and treatment plan.

90-Day Money-Back Guarantee

Third-Party Tested

Subscribe & Save Program

• Unclear Labels: Avoid products that don’t list all the different specific ingredients included in the formula’s detox blend.
• Missing Safety Testing & Certifications: Choose a cleanse product that has been independently third-party lab tested and manufactured in the USA to guarantee top quality and safety.
• Suspiciously Cheap Products: In this case, you do get what you pay for and it’s generally thought to be better to try to avoid products that rely primarily on harsh laxatives.*
• Japanese Star Anise: Sometimes confused with Chinese star anise, Japanese star anise (Illicium anisatum) contains toxins thought to be harmful but found in some “detox” supplements.* [6]