Generally, our bodies do a pretty good job of detoxing on their own. That being said, there are times when some people may want to give it a little helping hand. Research suggests that, when combined with some lifestyle changes, certain ingredients may help support the body’s own detoxification process. [2,3]

Who might potentially benefit from detox support?

• Feeling sluggish and sleepy*
• Having a heavy feeling in your stomach*
• Frequent bloating and excess gas that makes clothes feel tight*
• More breakouts or blackheads on your skin*
• Odor issues like bad breath or sweat that smells more than usual*
• Difficulty passing stools*
• Feeling backed up or being irregular*

• Popular ingredients include fennel seed, aloe vera leaf, lactobacillus acidophilus, and senna leaf
• Fair price
• Great customer service return policy
• Third-party laboratory tested

Look For

Our Choice

by Primal Harvest[1]

• US-made with globally sourced ingredients
• Contain herbs, fiber, and probiotics
• Easy-to-take capsules
• Free shipping on orders over $75

Based on 3732 Reviews of Primal Harvest 

What Some People Might Expect from Detox Support*

Everyone has individual needs and the experience of making changes in your wellness routine will vary from person to person. Here are some examples of how including more daily detox support may look for different people*:

What Some Might Expect From Detox Supplements:

1st Month

2nd Month

3rd Month

• Some people may notice that going to the bathroom is easy, making them feel light and energetic.* 
• At this point some people may begin to notice other changes in their digestion and energy, some might feel like their clothes fit comfortably after noticing less gas and being regular.* 
• This is when some people may feel that their skin looks clear, that they feel light, and are not paying attention to digestive concerns.* 

Try To Avoid

•  Trying to select the cheapest
• Trusting false reviews
• Not enough research 
• False claims
• Japanese star anise (Illicium anisatum)
• Unclear labels

2. Natural Colon Cleanser

PROS

• Herbal blend
• Includes probiotics
• Made in the USA

CONS

• No 90-day money-back guarantee
• No subscription program

BOTTOM LINE

Natural Colon Cleanser by The Enclare is formulated with a herbal blend and probiotics and is made in the USA. It contains ingredients like senna leaf, cascara sagrada, psyllium husk, licorice root, and L. acidophilus. However, the brand does not offer a 90-day money-back guarantee or a subscription program. 

B+

GRADE

5. ZuPoo Gut Support 

by UMZU

PROS

• Features cascara sagrada, fennel seed, and senna leaf 
• Taken once daily before bed 
• Made in CGMP facility 

CONS

•  Only a 15-day supply 
• No probiotics

BOTTOM LINE

ZuPoo Gut Support by UMZU features ingredients like cascara sagrada, fennel seed, and senna leaf. While this product features herbs, it does not contain probiotics. It is relatively easy to add to a routine, as users are instructed to take 2 capsules before bed once a day. That being said, some may want to note the price of the product and that it only contains a 15-day supply.

C

GRADE

by ColonBroom

PROS

• ColonBroom app
• Blended in the USA

CONS

• Price
• Contains 20 calories
• Precise timing of consumption

BOTTOM LINE

Colon Broom is a water-soluble powder supplement that is intended to be taken 1-2 times per day 30 minutes before a meal with an extra glass of water. Each scoop delivers 3.6 g of psyllium husk powder, the formula’s primary ingredient. This product provides 3 g of fiber and is manufactured in a GMP-certified facility. However, each serving also contains 20 calories as well as 60 mg of sodium. This formula may not be as easy to implement into a daily routine as some others, as it is recommended to be consumed about half an hour before a meal and must be drunk immediately otherwise thickening may occur, according to the consumption instructions provided. 

C+

GRADE

4. Colon Broom

3. Daily Cleanse

By HUM

PROS

• Includes minerals
• Formulated with plant extracts
• Third-party tested

CONS

• 30-day return policy
• No L. acidophilus

BOTTOM LINE

Daily Cleanse by HUM features ingredients like spirulina, chlorella, milk thistle, and beet root powder. Although it's formulated without probiotics, HUM’s Daily Cleanse does include the minerals zinc and selenium and comes in a 2-capsule per day serving. While it's fairly priced, some may want to note that it only comes with a 30-day return policy.

B

GRADE

• Formulated with herbal extracts, fiber, and antioxidants 
• Includes the probiotic L. acidophilus
• 2-capsule serving size
• 90-day money-back guarantee  
• Made in the USA with globally sourced ingredients
• Third-party lab tested

by Primal Harvest[1]

PROS

CONS

• Only available online
• Due to popularity, sometimes runs out of stock

Primal Total Cleanse by Primal Harvest features a varied blend of herbal extracts, antioxidants, fiber, and probiotics. It features a blend of ingredients like acai berry, fennel seeds, aloe vera leaf, senna leaf, cascara sagrada, ginger, flaxseed, oat bran, and Lactobacillus acidophilus. It contains all of this and more in just two capsules per day.

As all high-quality supplements should be, Primal Total Cleanse is third-party lab tested and made in the USA with globally sourced ingredients. The product offers great value for money and comes with a 90-day money-back guarantee. The brand has a convenient Subscribe & Save program which means you can order this formula through their convenient and hassle-free subscription service. By signing up for a subscription you get 20% off all products plus free shipping. 

BOTTOM LINE

A+

GRADE

by The Enclare

It’s estimated that there are at least 80,000 toxins surrounding us in our environment each day. Whether it’s toxin-laden foods, cosmetics, pollution, or an endless list of chemicals, toxins have become an accepted part of our modern world. [1]

What To Look For

Try To Avoid

Important Criteria

90-Day Money-Back Guarantee

Third-Party Tested

Natural Colon Cleanse by The Enclare 

Daily Cleanse by HUM

Colon Broom by ColonBroom

ZuPoo by UMZU

Top Detox & Cleanse Supplements in 2025

Fennel Seed

Aloe Vera Leaf

Lactobacillus Acidophilus

Senna Leaf

Cascara Sagrada

Oat Bran Fiber

Licorice Root

Acai Berry

No Japanese Star Anise

DISCLAIMER: This scientific research is for informational purposes only. The results reported may not necessarily occur in all individuals. Primal Harvest provides this information as a service but does not endorse it. This information should not be read to recommend or endorse any specific products.

1. “Fact Sheet: Potentially Toxic Chemicals in Personal Care Products.” New York Health Foundation, 7 Mar. 2019, https://nyhealthfoundation.org/resource/fact-sheet-potentially-toxic-chemicals-in-personal-care-products/. 

2. Allen J, Montalto M, Lovejoy J, Weber W. Detoxification…: a survey. J Altern Complement Med. 2011;17(12):1175-1180. doi:10.1089/acm.2010.0572. 

3. Crinnion WJ. Environmental medicine, part one: the human burden of environmental toxins and their common health effects. Altern Med Rev. 2000;5(1):52-63.

4. “Metabolic Waste.” Metabolic Waste - an Overview | ScienceDirect Topics, https://www.sciencedirect.com/topics/medicine-and-dentistry/metabolic-waste. 

5. Pizzorno, Joseph. “Toxins From the Gut.” Integrative medicine (Encinitas, Calif.) vol. 13,6 (2014): 8-11.

6. Madden GR, Schmitz KH, Fullerton K. A case of infantile star anise toxicity. Pediatr Emerg Care. 2012;28(3):284-285. doi:10.1097/PEC.0b013e3182495ba7

​

To see a list of our other references, please click here. 

CITATIONS

Note: We try to update product information as often as we can. Please visit product websites for more information.

Note: Individual results may vary. The benefits stated are based on personal experiences and subjective feedback and may vary from person to person.

Note: These statements are not intended to diagnose, treat, cure, or prevent any disease. Always consult your personal physician for an accurate diagnosis and treatment plan.

Factors To Consider Before Buying A Cleanse & Detox Supplement:

Top Cleanse Support Supplements in 2025

Everyone's needs are different, but some people who may benefit from taking a detox and cleanse support supplement include anyone who notices: