Here’s how to choose the best detox & cleansing formula for a total body reset in 2022

It’s estimated that there are at least 80,000 toxins surrounding us in our environment each day. Whether it’s toxin-laden foods, cosmetics, pollution, or an endless list of chemicals, toxins have become an accepted part of our modern world.

Fortunately, research has shown that, when combined with a healthy lifestyle, certain herbal extracts can help give your system a much needed reset and restore wellness by effectively pushing excess toxins and waste from your body.

Cleanse & Detox Supplement Must-Haves:

  • Fennel Seed: Rich in both antioxidants and fiber, fennel seeds have been shown to help relax your digestive muscles, support a healthy metabolic rate, normalize appetite, and prevent gas. 
  • Aloe Vera Leaf: Extremely hydrating and rich in phytonutrients, aloe vera has been historically used for centuries for its natural cleansing and antioxidant properties that support healthy detoxification.
  • Lactobacillus Acidophilus: Research has found that certain probiotics, especially Lactobacillus acidophilus, have properties that can bind to toxins and harmful pollutants in your body and aid in healthy detoxification.
  • Senna Leaf: Originally from Egypt, many studies have found that this gentle laxative can aid digestion and may even relieve occasional constipation, gas, and bloating.
  • Cascara Sagrada: Cascara sagrada is a cleansing herb and gentle laxative that has been traditionally used to help safely flush out toxins by emptying bowels and aiding with constipation and bloating.

Top Cleanse & Detox Supplements 2022


1533 votes







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90-Day Money-Back Guarantee  

Top-Rated Customer Support 

Easy-To-Swallow Capsules  

Holistic Formula with Herbal Extracts 

Certified Safety & Purity Testing 

Contains Probiotics

Only available online

Sometimes runs out of Stock

The Bottom Line

Primal Total Cleanse by Primal Harvest features a gentle yet effective blend of the top detoxifying ingredients to help eliminate waste and flush toxins from your body. Expertly formulated for natural and safe cleansing, it contains premium ingredients like acai berry fruit, fennel seeds, aloe vera leaf, senna leaf, cascara sagrada, and Lactobacillus acidophilus.

This premium cleanse formula provides a comprehensive approach to supporting energy, digestion, and healthy detoxification from a holistic wellness perspective, with no unnecessary fillers, synthetic additives, hidden ingredients or harsh laxatives. It was also one of very few products to include independent third-party lab testing, and abide by strict GMP manufacturing practices here in the USA.

This cleanse & detox supplement features superior value and quality at a reasonable price point. Their top-notch customer service scores and generous 90-day money-back guarantee is indicative of a brand that stands behind their customers and the quality of their products. When compared to other top competitors, Primal Total Cleanse by Primal Harvest was unrivaled in effectiveness, quality, safety, value, and customer service. 

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A+ Rating

1. Primal Total Cleanse

by Primal Harvest[1]

by Primal Harvest [1]

1834 Reviews

Primal Total Cleanse

  • US made with Premium Ingredients
  • Contain Herbs and Probiotics
  • Easy to Swallow Capsules
  • Made in a GMP Certified facility
  • Free Shipping on Orders over $75

2,367 people chose this today

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 Types of Toxins

What Are Toxins?

Anything that we eat, inhale, or place on our skin eventually makes its way into our bloodstream, where it then needs to be processed by our bodies (especially by the liver, colon, and kidneys).

Toxins, in the general sense, are waste products that your body cannot fully eliminate through digestion or other means. 

All cleanse and detox supplements are NOT created equal.

Unfortunately, many generic cleansing supplements are packed with synthetic fillers, artificial colouring, harsh laxatives, or a long list of chemical ingredients most people can’t even pronounce.

Here are the top things to avoid when shopping for a cleanse and detox supplement:

Top Cleansing Ingredients in Detox Supplements

Here are the top naturally detoxifying ingredients that meet today’s top criteria for safety, effectiveness, and value:

What To Avoid In Your Cleanse & Detox Supplement

  • Unclear Labels: Avoid products lacking transparency that don’t list all of the specific ingredients included in the formula’s detox blend.
  • Missing Safety Testing & Certifications: Choose a cleanse product that has been independently third party lab tested and manufactured in a GMP/NSP facility in the USA to guarantee top quality and safety.
  • False or Misleading Claims: Beware of any cleanse supplements that claim their product treats or cures any specific disease or ailment, or promises miraculous, unrealistic, or misleading results (such rapid weight loss).
  • Suspiciously Cheap Products: In this case, you do get what you pay for and it’s best to avoid low quality products that may contain harsh laxatives.
  • Japanese Star Anise: Sometimes confused with Chinese star anise, Japanese star anise contains sikimitoxin, a toxic ingredient that should never be consumed and that has been warned against by the USDA.

*Individual results may vary

Our Research-Backed 10-Point System

1. Price and Value for Money

2. Label Accuracy

3. Product Safety

4. Third Party Verifications

5. Customer Reviews

6. Guarantee & Return Policy

7. Product Quality & Benefits

8. Ingredient Purity & Sourcing

9. Possibility of Results

10.Science, Research, and Development

The Results: How We Picked Our Top Choice

We’ve carefully reviewed the sleep supplements available on the market today, examining customer reviews, conducting in-depth research, and surveying numerous consumers of top brands. Here are our top picks: 


Pizzorno, Joseph. “Toxins From the Gut.” Integrative medicine (Encinitas, Calif.) vol. 13,6 (2014): 8-11.

Roundtable on Environmental Health Sciences, Research, and Medicine; Board on Population Health and Public Health Practice; Institute of Medicine. Identifying and Reducing Environmental Health Risks of Chemicals in Our Society: Workshop Summary. Washington (DC): National Academies Press (US); 2014 Oct 2. 3, Current Regulatory Approaches to Dealing with Industrial Chemicals.

Pizzorno, Joseph. “Is the Diabetes Epidemic Primarily Due to Toxins?.” Integrative medicine (Encinitas, Calif.) vol. 15,4 (2016): 8-17.

Sutton, Patrice et al. “Toxic environmental chemicals: the role of reproductive health professionals in preventing harmful exposures.” American journal of obstetrics and gynecology vol. 207,3 (2012): 164-73. doi:10.1016/j.ajog.2012.01.034

Pizzorno, Joseph. “Toxin Exposure Reduction.” Integrative medicine (Encinitas, Calif.) vol. 16,6 (2017): 8-10.

Henkel, James S et al. “Toxins from bacteria.” EXS vol. 100 (2010): 1-29. doi:10.1007/978-3-7643-8338-1_1

Fasano, A. “Toxins and the gut: role in human disease.” Gut vol. 50 Suppl 3,Suppl 3 (2002): III9-14. doi:10.1136/gut.50.suppl_3.iii9

Barrett, Julia R. “The ugly side of beauty products.” Environmental health perspectives vol. 113,1 (2005): A24. doi:10.1289/ehp.113-a24

Piazza, Mauri José, and Almir Antônio Urbanetz. “Environmental toxins and the impact of other endocrine disrupting chemicals in women's reproductive health.” JBRA assisted reproduction vol. 23,2 154-164. 30 Apr. 2019, doi:10.5935/1518-0557.20190016

Cohen M. Environmental toxins and health--the health impact of pesticides. Aust Fam Physician. 2007 Dec;36(12):1002-4. PMID: 18075622.

Crinnion WJ. Environmental medicine, part one: the human burden of environmental toxins and their common health effects. Altern Med Rev. 2000 Feb;5(1):52-63. PMID: 10696119.

Pizzorno, Joseph. “Conventional Laboratory Tests to Assess Toxin Burden.” Integrative medicine (Encinitas, Calif.) vol. 14,5 (2015): 8-16.

Phillips DH, Arlt VM. Genotoxicity: damage to DNA and its consequences. EXS. 2009;99:87-110. doi: 10.1007/978-3-7643-8336-7_4. PMID: 19157059.

Genuis, Stephen J et al. “Clinical detoxification: elimination of persistent toxicants from the human body.” TheScientificWorldJournal vol. 2013 238347. 6 Jun. 2013, doi:10.1155/2013/238347

National Research Council (US) Committee on National Monitoring of Human Tissues. Monitoring Human Tissues for Toxic Substances. Washington (DC): National Academies Press (US); 1991. 3, Toxicologic Issues.

Allen, Jason et al. “Detoxification in naturopathic medicine: a survey.” Journal of alternative and complementary medicine (New York, N.Y.) vol. 17,12 (2011): 1175-80. doi:10.1089/acm.2010.0572

Badgujar, Shamkant B et al. “Foeniculum vulgare Mill: a review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology.” BioMed research international vol. 2014 (2014): 842674. doi:10.1155/2014/842674

Singh B, Kale RK. Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system. Food Chem Toxicol. 2008 Dec;46(12):3842-50. doi: 10.1016/j.fct.2008.10.008. Epub 2008 Oct 14. PMID: 18976688.

Lee HS, Kang P, Kim KY, Seol GH. Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-κB Activation. Korean J Physiol Pharmacol. 2015 Mar;19(2):183-9. doi: 10.4196/kjpp.2015.19.2.183. Epub 2015 Feb 25. PMID: 25729281; PMCID: PMC4342739.

Khedmat, Hossein et al. “Aloe vera in treatment of refractory irritable bowel syndrome: Trial on Iranian patients.” Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences vol. 18,8 (2013): 732.

Surjushe, Amar et al. “Aloe vera: a short review.” Indian journal of dermatology vol. 53,4 (2008): 163-6. doi:10.4103/0019-5154.44785

Ibrahim F, Halttunen T, Tahvonen R, Salminen S. Probiotic bacteria as potential detoxification tools: assessing their heavy metal binding isotherms. Can J Microbiol. 2006 Sep;52(9):877-85. doi: 10.1139/w06-043. PMID: 17110980.

Zoghi A, Khosravi-Darani K, Sohrabvandi S. Surface binding of toxins and heavy metals by probiotics. Mini Rev Med Chem. 2014 Jan;14(1):84-98. doi: 10.2174/1389557513666131211105554. PMID: 24329992.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Senna. [Updated 2020 Apr 1].

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Cascara. [Updated 2017 Jan 23].

Center for Food Safety and Applied Nutrition 2003. U.S. Food & Drug Administration.

Madden GR, Schmitz KH, Fullerton K. A case of infantile star anise toxicity. Pediatr Emerg Care. 2012 Mar;28(3):284-5. doi: 10.1097/PEC.0b013e3182495ba7. PMID: 22391927.

*Always consult your personal physician for an accurate diagnosis and treatment plan.

*These statements are not intended to diagnose, treat, cure or prevent any disease.

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372 votes







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Contains Quality Natural Ingredients  

Formulated in The USA

GMP certified 

15-Day Detox is a bold claim

Some users report feeling very little difference after 1 bottle

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B+ Rating

2. 15 Day Cleanse

by Youth & Tonic

15 Day Cleanse by Youth & Tonic features 30 veggie capsules containing quality natural ingredients. This product was formulated in the USA and aims at providing constipation relief and regular bowl movement support for those who experience mild problems, and need gentle relief. The other ingredients aim to clean the colon, and it is recommended to increase water intake when starting this product. 


937 votes







Ingredient Quality Control

Potency & Estimated Efficacy

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Easy to swallow soft capsules

There is no product that can detox the body in 5 Days

Questionable efficacy in comparison to other brands

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C Rating

4. Detox

by Cannabiology

Detox by Cannabiology is a great option for vegans and those who need soft capsules. But, some of the claims are too strong to be taken seriously. On a positive note, the company is great at addressing customer's concerns, and cranberry extract can have positive effects for cleaning out toxins in the body and preventing UTIs. 


567 votes







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Price / Customer Value

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Formulated to clean and repair the liver

Manufactured in the USA and made from non-GMO, plant-bassed ingredients.

Contains gluten which can upset leaky gut

Some users reported feeling ill, and even some minor swelling after taking this product. 

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C+ Rating

3. Liver 21 Day Cleanse

by Dr. Tobias

Liver 21 Day Cleanse by Dr. Tobias was formulated to help cleanse and repair the liver but contains gluten and wheat, which can cause some upset stomachs and even worsen leaky gut in some situations. This product is manufactured in the USA from non-GMO, plant-based ingredients, and is third-party tested for purity, effectiveness, and safety. 


248 votes







Ingredient Quality Control

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Contains probiotics and powerful herbs

Made in the USA, non-GMO, and keto friendly 

Products claims to be vegetarians but contains gelatin

Many users experienced diarrhea

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C Rating

5. Natural Colon Cleanser

by The Enclare

Natural Colon Cleanser 15 Day Detox by The Enclare made the final spot on our list because it is offers a complete formula, but many users experienced negative effects while taking this product. Diarrhea, abdominal pain, cramping, etc.  Another issue with this product is that it claims to be suitable for vegetarians but the capsules are made from bovine gelatine, so make sure to read the label if you follow a specialty diet. 

The Top Detox & Cleanse Supplements of 2022

Latest update: January 2, 2022

 Top Reviews

Unique Features


Costs & More


Cellular waste products (Also known as metabolic waste)

Environmental (Like those found in air pollution, household products, and cosmetics)

Bacteria from the digestive tract (Bacterial toxins that can form in your digestive tract)

 Toxins May Damage the Body By...

Most of the time, a healthy body is able to neutralize toxins coming in and maintain normal homeostasis, but this isn’t always the case. Symptoms of toxin overload can include gas, bloating, constipation, diarrhea, headaches, breakouts, lethargy, fatigue, bad breath, foul-smelling sweat, and more.

Disrupting healthy hormone function and balance 

Harming important enzymes so that they can no longer function properly 

Displacing minerals like calcium that are needed to prevent bone loss 

Speeding up the aging process by potentially damaging DNA 

Weakening the body’s ability to detoxify, possibly the most dangerous issue 

And more...

What Type of Cleanse Supplement is Best?

Spotting the ultimate detox support supplement doesn’t need to be complicated. There are a few key must-haves you need to look for when choosing the right product for you.

Fortunately, we’ve done the homework for you. Based on expert advice, clinical studies, in-depth research, and honest feedback from informed shoppers, here are our top choices.

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© 2022

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These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information provided by this website or this company is not a substitute for a face-to-face consultation with your physician and should not be construed as individual medical advice. The testimonials on this website are individual cases and do not guarantee that you will get the same results. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only.

Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Smarter Choices has with our top picks.

[1] we have a financial relationship with some of our top picks and partners